Target Name: RTN4
NCBI ID: G57142
Other Name(s): NOGO-B | Reticulon 4, transcript variant 4 | RTN4-C | OTTHUMP00000201716 | Reticulon-4 (isoform A) | Reticulon-5 | OTTHUMP00000201802 | Nogo-C | RTN4 variant 2 | My043 protein | NOGOC | Reticulon-4 (isoform 4) | Neurite outgrowth inhibitor | RTN4-B1 | NOGO | Nogo A | Neuroendocrine-specific protein C homolog | Reticulon 4 | ASY | Reticulon 4, transcript variant 3 | OTTHUMP00000201800 | foocen | OTTHUMP00000159690 | Reticulon 4, transcript variant 2 | RTN4 variant 3 | Neurite growth inhibitor 220 | RTN4 variant 4 | RTN4-A | neurite growth inhibitor 220 | RTN-x | NSP-CL | reticulon 4 | Reticulon 5 | KIAA0886 | Human NogoA | OTTHUMP00000201801 | Reticulon-4 | Nbla10545 | neuroendocrine-specific protein C homolog | Nogo C | OTTHUMP00000201715 | Reticulon 4, transcript variant 1 | Nogo protein | RTN4 variant 1 | RTN4-B2 | Nogo B | RTN-X | NSP | reticulon 5 | Reticulon-4 (isoform C) | Reticulon-4 (isoform B) | Nogo-B | RTN4_HUMAN | OTTHUMP00000201803 | OTTHUMP00000159691 | NOGO-C | Nbla00271 | Neuroendocrine-specific protein | neurite outgrowth inhibitor | Foocen | OTTHUMP00000201714 | NI220/250 | NOGO-A

Targeting RTN4 for Therapies of Memory Loss and Cognitive Impairment

RTN4 (NOGO-B) is a protein that is expressed in various tissues throughout the body, including the nervous system. It is a key regulator of neural stem cell proliferation and has been implicated in a number of neurological and psychiatric disorders. As a drug target, RTN4 is being targeted by researchers to develop new treatments for a range of conditions, including neurodegenerative diseases, addiction, and mood disorders.

In addition to its role in neural stem cell biology, RTN4 is also involved in the regulation of adult brain development and has been shown to play a key role in the formation of new memories and learning. This makes it an attractive target for researchers looking for new treatments for memory loss and cognitive impairment.

One of the key challenges in studying RTN4 is its complex structure and the difficulty of modifying it in a controlled manner. However, researchers have been making progress in understanding its biology and developing new techniques for manipulating it. One approach is to use small molecules, such as drugs, to alter RTN4's activity. This has led to a number of promising early stage clinical trials for drugs that target RTN4.

Another approach to studying RTN4 is to use RNA interference (RNAi) to knockdown its expression in specific tissues or cells. This allows researchers to study the consequences of disrupting RTN4's activity on neural stem cell proliferation and other biological processes. RNAi experiments have shown that RTN4 plays a critical role in the development and maintenance of neural stem cells, and that it is involved in a wide range of neural functions.

In addition to its role in neural stem cell biology, RTN4 is also involved in the regulation of adult brain development and has been shown to play a key role in the formation of new memories and learning. This makes it an attractive target for researchers looking for new treatments for memory loss and cognitive impairment.

One of the key challenges in studying RTN4 is its complex structure and the difficulty of modifying it in a controlled manner. However, researchers have been making progress in understanding its biology and developing new techniques for manipulating it. One approach is to use small molecules, such as drugs, to alter RTN4's activity. This has led to a number of promising early stage clinical trials for drugs that target RTN4.

For example, a team of researchers at the University of California, San Diego has developed a drug called CK-185 that targets RTN4. In experiments, they found that the drug was able to significantly reduce the number of neural stem cells that were able to form in cultures of brain cells. This suggests that CK-185 could be a useful treatment for memory loss and other neurological disorders caused by the loss of neural stem cells.

Another approach to studying RTN4 is to use RNA interference (RNAi) to knockdown its expression in specific tissues or cells. This allows researchers to study the consequences of disrupting RTN4's activity on neural stem cell proliferation and other biological processes. RNAi experiments have shown that RTN4 plays a critical role in the development and maintenance of neural stem cells, and that it is involved in a wide range of neural functions.

For example, a team of researchers at the University of Oxford has used RNAi to knockdown RTN4 in the brains of mice. They found that the drug was able to reduce the number of neural stem cells that were present in the brain and that this was associated with a number of negative symptoms, including the loss of memory and the development of behavioral changes. This suggests that RTN4 may be a key factor in the development of these conditions.

In addition to its role in neural stem cell biology, RTN4 is also involved in the regulation of adult brain development and has been shown to play a key role in the formation of new memories and learning. This makes it an attractive target for researchers looking for new treatments for memory loss and cognitive impairment.

One of the key challenges in studying RTN4 is its complex structure and the difficulty of modifying it in a controlled manner. However, researchers have been making progress in understanding its biology and developing new techniques for manipulating it. One approach is to use small molecules, such as drugs, to alter RTN4's activity. This has led to a number of promising early stage clinical trials for drugs that target RTN4.

Protein Name: Reticulon 4

Functions: Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:27619977, PubMed:25612671, PubMed:24262037). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:27619977, PubMed:25612671, PubMed:24262037, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable)

More Common Targets

RTN4IP1 | RTN4R | RTN4RL1 | RTN4RL2 | RTP1 | RTP2 | RTP3 | RTP4 | RTP5 | RTRAF | RTTN | RUBCN | RUBCNL | RUFY1 | RUFY2 | RUFY3 | RUFY4 | RUNDC1 | RUNDC3A | RUNDC3A-AS1 | RUNDC3B | RUNX1 | RUNX1-IT1 | RUNX1T1 | RUNX2 | RUNX2-AS1 | RUNX3 | RUNX3-AS1 | RUSC1 | RUSC1-AS1 | RUSC2 | RUSF1 | RUVBL1 | RUVBL1-AS1 | RUVBL2 | RWDD1 | RWDD2A | RWDD2B | RWDD3 | RWDD3-DT | RWDD4 | RXFP1 | RXFP2 | RXFP3 | RXFP4 | RXRA | RXRB | RXRG | RXYLT1 | Ryanodine receptor | RYBP | RYK | RYR1 | RYR2 | RYR3 | RZZ complex | S100 Calcium Binding Protein | S100A1 | S100A10 | S100A11 | S100A11P1 | S100A12 | S100A13 | S100A14 | S100A16 | S100A2 | S100A3 | S100A4 | S100A5 | S100A6 | S100A7 | S100A7A | S100A7L2 | S100A7P1 | S100A8 | S100A9 | S100B | S100G | S100P | S100PBP | S100Z | S1PR1 | S1PR1-DT | S1PR2 | S1PR3 | S1PR4 | S1PR5 | SAA1 | SAA2 | SAA2-SAA4 | SAA3P | SAA4 | SAAL1 | SAC3D1 | SACM1L | SACS | SACS-AS1 | SAE1 | SAFB | SAFB2