S100A3: Potential Drug Target Or Biomarker (G6274)

Target Name: S100A3

NCBI ID: G6274

S100A3: Potential Drug Target Or Biomarker

S100A3, also known as protein S100-A3, is a protein that is expressed in various tissues throughout the body. It is a member of the S100 family of proteins, which are known for their role in cell signaling and stress responses. S100A3 has been shown to play a role in a variety of biological processes, including cell signaling, inflammation, and the regulation of ion channels. As a result, S100A3 has potential as a drug target or biomarker.

S100A3 is a 21-kDa protein that is expressed in various tissues, including the brain, heart, liver, and kidneys. It is a member of the S100 family of proteins, which are characterized by the presence of a basic amino acid residue at their C-terminus. This basic residue is important for the protein's stability and can modulate its function in a variety of ways.

One of the key functions of S100A3 is its role in cell signaling. S100A3 has been shown to play a role in a variety of signaling pathways, including the regulation of cell proliferation and the regulation of ion channels. For example, studies have shown that S100A3 can interact with the protein FERMT1 and regulate the formation of new blood vessels. Additionally, S100A3 has been shown to play a role in the regulation of ion channels, including the regulation of neurotransmitter release and the regulation of muscle contractions.

In addition to its role in cell signaling, S100A3 is also involved in the regulation of inflammation. Studies have shown that S100A3 can interact with the protein NF-kappa-B and regulate the expression of genes involved in inflammation. This suggests that S100A3 may play a role in the regulation of inflammatory responses and may be a potential therapeutic target for the treatment of inflammatory disorders.

S100A3 has also been shown to play a role in the regulation of cell adhesion. Studies have shown that S100A3 can interact with the protein cadherin and regulate the formation of tight junctions, which are important for the regulation of cell-cell adhesion. This suggests that S100A3 may play a role in the regulation of cell adhesion and may be a potential therapeutic target for the treatment of diseases that are characterized by disrupted cell-cell adhesion, such as cancer.

Another potential function of S100A3 is its role in the regulation of neurotransmission. Studies have shown that S100A3 can interact with the protein neurotrophin and regulate the release of neurotransmitters, including dopamine and serotonin. This suggests that S100A3 may play a role in the regulation of neurotransmission and may be a potential therapeutic target for the treatment of neurotransmission disorders.

In conclusion, S100A3 is a protein that has been shown to play a variety of roles in various biological processes. Its basic amino acid residue, as well as its ability to interact with other proteins, suggest that it has potential as a drug target or biomarker. Further research is needed to fully understand the functions of S100A3 and its potential as a therapeutic target.

Protein Name: S100 Calcium Binding Protein A3

Functions: Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation

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