S100A1: A Protein Involved in Calcium Signaling and Multiple Cellular Processes

Target Name: S100A1

NCBI ID: G6271

S100A1: A Protein Involved in Calcium Signaling and Multiple Cellular Processes

S100A1, also known as S100A1 protein, is a protein that is expressed in various tissues throughout the body. It is a member of the S100 family of proteins, which are known for their ability to interact with and regulate the activity of various signaling pathways. One of the most well-known S100 proteins is S100A1, which is a calcium-binding protein that is involved in a number of different cellular processes.

S100A1 is a type of transmembrane protein that is composed of four constant and one variable region. It is expressed in a variety of tissues, including muscle, nerve, heart, and brain. S100A1 is primarily localized to the cytoplasm of cells, where it can interact with various signaling molecules to regulate a wide range of cellular processes.

One of the most significant functions of S100A1 is its role in calcium signaling. S100A1 is a critical protein for regulating the levels of calcium ions in cells, which are essential for a wide range of cellular processes. When calcium ions are released from the inside of a cell, they can interact with S100A1, allowing it to regulate the amount of calcium ions that are released. This is important for maintaining the stability of cellular processes and for ensuring the proper functioning of cells.

In addition to its role in calcium signaling, S100A1 is also involved in a number of other cellular processes. For example, it has been shown to play a role in the regulation of cell adhesion, as well as in the regulation of the migration and survival of cells. S100A1 has also been shown to interact with a variety of signaling molecules, including TGF-β, NF-kappa-B, and PI3K.

S100A1 is also of interest as a potential drug target. Due to its involvement in a wide range of cellular processes, S100A1 is a promising target for the development of new pharmaceuticals. For example, S100A1 has been shown to play a role in the regulation of cell division, which could make it a potential target for drugs that are designed to inhibit cell division. In addition, S100A1 has also been shown to play a role in the regulation of cell death, which could make it a potential target for drugs that are designed to induce cell death.

Overall, S100A1 is a protein that is involved in a wide range of cellular processes. Its role in calcium signaling and its involvement in the regulation of various cellular processes make it a promising target for the development of new pharmaceuticals. Further research is needed to fully understand the functions of S100A1 and to determine its potential as a drug target.

Protein Name: S100 Calcium Binding Protein A1

Functions: Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed:12804600). In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes (PubMed:23351007). These changes allow interactions with specific target proteins and modulate their activity (PubMed:22399290). Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase (PubMed:12804600). Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole (PubMed:11717446)

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