SCTR: A Protein Targeted for Cancer and Neurodegenerative Diseases

Target Name: SCTR

NCBI ID: G6344

SCTR: A Protein Targeted for Cancer and Neurodegenerative Diseases

SCTR (SCT-R) is a protein that is expressed in various tissues of the body, including the brain, heart, lungs, and kidneys. It is a key regulator of cell proliferation and survival, and has been implicated in a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a drug target, SCTR is a promising target for the development of new treatments for a variety of diseases.

SCTR was first identified in the 1990s as a potential drug target for cancer. It has since been shown to be involved in the regulation of cell proliferation, apoptosis (programmed cell death), and angiogenesis (the formation of new blood vessels). SCTR has also been shown to play a role in the regulation of neurotransmitter signaling, which is critical for the function of the brain and other nervous system cells.

SCTR has been shown to be involved in the development and progression of a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. For example, studies have shown that high levels of SCTR are associated with an increased risk of the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease.

In addition to its potential role in disease, SCTR is also a valuable drug target because it is relatively easy to target. Unlike many other proteins, which are involved in a complex process and are difficult to study, SCTR has a single, well-studied function. This makes it easier to understand how SCTR works and to develop potential treatments.

One of the challenges in studying SCTR as a drug target is its complex role in various biological processes. SCTR is involved in the regulation of cell proliferation, apoptosis, and angiogenesis, and it is also involved in the regulation of neurotransmitter signaling. This makes it difficult to understand how SCTR interacts with other proteins and how it contributes to the complex processes that are involved in these processes.

To overcome this challenge, researchers have used a variety of techniques to study SCTR. For example, they have used RNA interference techniques to knock down the expression of SCTR and to study its function. They have also used live cell imaging techniques to study the behavior of SCTR in the cell and how it interacts with other proteins.

In addition to these techniques, researchers have also used computational tools to study the structure and function of SCTR. This has allowed them to gain new insights into the protein's role in various biological processes and to identify potential drug targets.

Overall, SCTR is a protein that is widely expressed in various tissues of the body and is involved in a number of biological processes. As a drug target, it is a promising target for the development of new treatments for a variety of diseases. Further research is needed to fully understand the role of SCTR in these processes and to identify potential drug targets.

Protein Name: Secretin Receptor

Functions: Receptor for secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis (PubMed:7612008, PubMed:25332973). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). Upon binding to secretin, regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes. Also plays an important role in cellular osmoregulation by regulating renal water reabsorption. Also plays a role in the central nervous system: required for synaptic plasticity (By similarity)

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