GFRA4: A GPCR Targeted for Cancer and Other Diseases (G64096)
GFRA4: A GPCR Targeted for Cancer and Other Diseases
GFRA4 (G protein-coupled receptor type 4) is a protein that is expressed in various tissues and cells in the body. It is a member of the G protein-coupled receptor (GPCR) family, which is a large superfamily of transmembrane proteins that play an important role in cellular signaling. GPCR signaling pathways have been implicated in many diseases, including cancer, neurodegenerative diseases, and psychiatric disorders. As a result, GFRA4 has become a focus of interest in recent years as a potential drug target or biomarker.
GFRA4 is a protein that is composed of 115 amino acid residues and has a calculated molecular weight of 13.9 kDa. It is expressed in a variety of tissues and cells, including the brain, pancreas, and heart. GFRA4 is a GPCR that is involved in the regulation of cellular processes such as cell growth, differentiation, and survival. It is a prototype of a family of GPCRs that includes GFR伪1, GFR伪2, GFR伪3, GFR伪4, GFR伪5, GFR伪6, GFR伪7, GFR伪8, GFR伪9, GFR伪10, GFR伪11, GFR伪12, GFR伪13, GFR伪14, GFR伪15, GFR伪16, GFR伪17, GFR伪18, GFR伪19, GFR伪20, GFR伪21, GFR伪22, GFR伪23, GFR伪24, GFR伪25, GFR伪26, GFR伪27, GFR伪28, GFR伪29, GFR伪30, GFR伪31, GFR伪32, GFR伪33, GFR伪34, GFR伪35, GFR伪36, GFR伪37, GFR伪38, GFR伪39, GFR伪40, GFR伪41, GFR伪42, GFR伪43, GFR伪44, GFR伪45, GFR伪46, GFR伪47, GFR伪48, GFR伪49, GFR伪50, GFR伪51, GFR伪52, GFR伪53, GFR伪54, GFR伪55, GFR伪56, GFR伪57, GFR伪58, GFR伪59, GFR伪60, GFR伪61, GFR伪62, GFR伪63, GFR伪64, GFR伪65, GFR伪66, GFR伪67, GFR伪68, GFR伪69, GFR伪70, GFR伪71, GFR伪72, GFR伪73, GFR伪74, GFR伪75, GFR伪76, GFR伪77, GFR伪78, GFR伪79, GFR伪80, GFR伪81, GFR伪82, GFR伪83, GFR伪84, GFR伪85, GFR伪86, GFR伪87, GFR伪88, GFR伪89, GFR伪90, GFR伪91, GFR伪92, GFR伪93, GFR伪94, GFR伪95, GFR伪96, GFR伪97, GFR伪98, GFR伪99, GFR伪100, and GFR伪101.
GFRA4 is a member of the GPCR family of proteins that are characterized by the presence of a transmembrane domain and an intracellular signaling loop. The transmembrane domain is responsible for the delivery of the signaling molecule,
Protein Name: GDNF Family Receptor Alpha 4
Functions: Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla
More Common Targets
GFRAL | GFUS | GGA1 | GGA2 | GGA3 | GGACT | GGCT | GGCX | GGH | GGN | GGNBP1 | GGNBP2 | GGPS1 | GGT1 | GGT2P | GGT3P | GGT5 | GGT6 | GGT7 | GGT8P | GGTA1 | GGTLC1 | GGTLC2 | GGTLC3 | GH1 | GH2 | GHDC | GHITM | GHR | GHRH | GHRHR | GHRL | GHRLOS | GHSR | GID4 | GID8 | GIGYF1 | GIGYF2 | GIHCG | GIMAP1 | GIMAP1-GIMAP5 | GIMAP2 | GIMAP3P | GIMAP4 | GIMAP5 | GIMAP6 | GIMAP7 | GIMAP8 | GIMD1 | GIN1 | GINM1 | GINS complex | GINS1 | GINS2 | GINS3 | GINS4 | GIP | GIPC1 | GIPC2 | GIPC3 | GIPR | GIT1 | GIT2 | GJA1 | GJA10 | GJA1P1 | GJA3 | GJA4 | GJA5 | GJA8 | GJA9 | GJA9-MYCBP | GJB1 | GJB2 | GJB3 | GJB4 | GJB5 | GJB6 | GJB7 | GJC1 | GJC2 | GJC3 | GJD2 | GJD3 | GJD4 | GK | GK2 | GK3 | GK5 | GKAP1 | GKN1 | GKN2 | GKN3P | GLA | GLB1 | GLB1L | GLB1L2 | GLB1L3 | GLC1C | GLCCI1
