ZNF134: Key Regulator of Neural Development and Disease (G7693)
ZNF134: Key Regulator of Neural Development and Disease
ZNF134 (ZN134_HUMAN), a protein encoded by the ZNF1 gene, is a key regulator of neural development, cell survival, and plasticity. The ZNF1 gene is located on chromosome 6p21.3 and has been implicated in various neurological and psychiatric disorders, including autism , schizophrenia, and mood disorders. ZNF134 has been identified as a potential drug target and biomarker for several diseases, including neurological disorders, cancer, and aging.
The ZNF1 gene is a member of the ZNF family, which includes several transcription factor family members. These transcription factors are involved in the regulation of gene expression and play a crucial role in the development and maintenance of neural tissues. The ZNF1 gene is responsible for the production of ZNF1, a protein that has been shown to play a crucial role in the regulation of neural development and cell survival.
ZNF134 is a 21-kDa transmembrane protein that is expressed in various tissues, including brain, spinal cord, and peripheral tissues. It is highly conserved, with a calculated pI of 5.5 and a predicted localization in the cell membrane as a protein that is involved in the regulation of intracellular signaling pathways. ZNF134 is known to interact with several other proteins, including NF-kappa-B, TGF-β, and p53. These interactions are important for the regulation of neural development, cell survival, and plasticity.
ZNF134 has been shown to play a role in the regulation of neural development and cell survival. It has been shown to be involved in the development and maintenance of neural stem cells, which are a crucial source of cells for the development and repair of neural tissues . ZNF134 has also been shown to be involved in the regulation of cell apoptosis, which is a critical mechanism for the regulation of cell numbers and survival.
In addition to its role in neural development and cell survival, ZNF134 has also been shown to play a role in the regulation of cellular signaling pathways. It has been shown to be involved in the regulation of several intracellular signaling pathways, including the TGF-β pathway, the PI3K/Akt pathway, and the NF-kappa-B pathway. These signaling pathways are important for the regulation of cellular processes such as cell growth, differentiation, and survival.
The ZNF134 gene has also been implicated in the development and progression of several neurological and psychiatric disorders, including autism, schizophrenia, and mood disorders. ZNF134 has been shown to be involved in the regulation of the development and progression of these disorders, and may play a role in the development of these conditions.
In addition to its potential role in the development and progression of neurological and psychiatric disorders, ZNF134 has also been identified as a potential drug target and biomarker for several diseases. For example, ZNF134 has been shown to be involved in the regulation of the development and progression of cancer, and may be a useful biomarker for the diagnosis and treatment of cancer. ZNF134 has also been shown to be involved in the regulation of aging, and may be a useful target for therapies aimed at delaying aging.
In conclusion, ZNF134 is a key regulator of neural development, cell survival, and plasticity, and has been implicated in the development and progression of several neurological and psychiatric disorders. Its potential as a drug target and biomarker makes it an attractive target for the development of new therapies for these conditions. Further research is needed to fully understand the role of ZNF134 in neural development and disease, and to develop effective treatments based on this understanding.
Protein Name: Zinc Finger Protein 134
Functions: May be involved in transcriptional regulation
More Common Targets
ZNF135 | ZNF136 | ZNF137P | ZNF138 | ZNF14 | ZNF140 | ZNF141 | ZNF142 | ZNF143 | ZNF146 | ZNF148 | ZNF154 | ZNF155 | ZNF157 | ZNF16 | ZNF160 | ZNF165 | ZNF169 | ZNF17 | ZNF174 | ZNF175 | ZNF177 | ZNF18 | ZNF180 | ZNF181 | ZNF182 | ZNF184 | ZNF185 | ZNF189 | ZNF19 | ZNF195 | ZNF197 | ZNF2 | ZNF20 | ZNF200 | ZNF202 | ZNF204P | ZNF205 | ZNF205-AS1 | ZNF207 | ZNF208 | ZNF209P | ZNF211 | ZNF212 | ZNF213 | ZNF213-AS1 | ZNF214 | ZNF215 | ZNF217 | ZNF219 | ZNF22 | ZNF22-AS1 | ZNF221 | ZNF222 | ZNF223 | ZNF224 | ZNF225 | ZNF225-AS1 | ZNF226 | ZNF227 | ZNF229 | ZNF23 | ZNF230 | ZNF232 | ZNF232-AS1 | ZNF233 | ZNF234 | ZNF235 | ZNF236 | ZNF236-DT | ZNF239 | ZNF24 | ZNF248 | ZNF25 | ZNF250 | ZNF251 | ZNF252P | ZNF252P-AS1 | ZNF253 | ZNF254 | ZNF256 | ZNF257 | ZNF26 | ZNF260 | ZNF263 | ZNF264 | ZNF266 | ZNF267 | ZNF268 | ZNF271P | ZNF273 | ZNF274 | ZNF275 | ZNF276 | ZNF277 | ZNF28 | ZNF280A | ZNF280B | ZNF280C | ZNF280D
