TNFRSF10A: A Protein Targeted for Drug Development (G8797)

Target Name: TNFRSF10A

NCBI ID: G8797

TNFRSF10A: A Protein Targeted for Drug Development

TNFRSF10A (CD261) is a protein that is expressed in a variety of tissues throughout the body, including the skin, hair, and nervous system. It is a member of the TNF-related signaling family (TNFS), which includes several other proteins that play important roles in tissue repair and regeneration.

One of the key functions of TNFRSF10A is its role in the regulation of inflammation. TNFRSF10A has been shown to play a negative role in the inflammatory response, by promoting the production of regulatory T cells that help to maintain tissue homeostasis and prevent excessive tissue inflammation.

In addition to its role in inflammation, TNFRSF10A is also involved in several other cellular processes that are important for tissue development and maintenance. For example, it has been shown to promote the migration of cells, such as stem cells and neural cells, to their proper locations in the body, where it is necessary for their function and survival.

Given its involvement in a variety of important cellular processes, it is not surprising that TNFRSF10A has been identified as a potential drug target. Researchers are currently working to develop small molecules that can specifically modulate the activity of TNFRSF10A, with the goal of using these drugs to treat a variety of diseases.

One approach that is being explored is the use of small molecules that can inhibit the activity of TNFRSF10A. These molecules have been shown to be effective in treating a variety of conditions, including cancer, autoimmune diseases, and wound healing.

Another approach that is being explored is the use of small molecules that can enhance the activity of TNFRSF10A. These molecules have been shown to be effective in treating a variety of conditions, including cancer, autoimmune diseases, and neurodegenerative diseases.

While the use of small molecules to modulate the activity of TNFRSF10A is still in its early stages, it holds great promise as a potential drug target. Further research is needed to fully understand the molecular mechanisms that are involved in the regulation of TNFRSF10A, and to develop safe and effective drugs that can be used to treat a variety of diseases.

Protein Name: TNF Receptor Superfamily Member 10a

Functions: Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (PubMed:19090789). Promotes the activation of NF-kappa-B (PubMed:9430227)

More Common Targets