Target Name: RTN3
NCBI ID: G10313
Other Name(s): Reticulon-3 | Reticulon 3, transcript variant 1 | neuroendocrine-specific protein-like 2 | NSP-like protein 2 | NSP-like protein II | NSPL2 | Neuroendocrine-specific protein-like II | ASY interacting protein | RTN3 variant 1 | Reticulon-3 (isoform a) | OTTHUMP00000237754 | OTTHUMP00000237757 | OTTHUMP00000237755 | Reticulon 3 | NSPLII | RTN3-A1 | OTTHUMP00000237756 | ASYIP | OTTHUMP00000237759 | reticulon 3 | HAP | neuroendocrine-specific protein-like II | RTN3_HUMAN | Neuroendocrine-specific protein-like 2 | Homolog of ASY protein | homolog of ASY protein

RTN3: A Potential Drug Target and Biomarker

RTN3 (Reticulon-3) is a protein that is expressed in various tissues and cells of the human body. It is a member of the retinoic acid receptor (RAR) family, which is a well-established gene family that plays a crucial role in the development and maintenance of tissues with specific functions, such as eyes, hair, and nails. The RAR family also includes the RXR gene, which encodes for the retinoblastoma gene (RB).

While RTN3 has been identified as a potential drug target and biomarker, more research is needed to fully understand its role in the body and its potential as a therapeutic agent.

The RAR family of proteins is involved in the regulation of gene expression and cell signaling. The RAR proteins function by binding to specific DNA sequences and regulating the activity of various transcription factors. These transcription factors are responsible for transmitting genetic information from the DNA to the ribosome, which then synthesizes proteins. By binding to specific DNA sequences, the RAR proteins can either activate or inhibit the activity of these transcription factors.

RTN3 is a 21-kDa protein that is expressed in various tissues and cells of the body. It is highly conserved, with a calculated identity of 97% at the amino acid level and a calculated fold of 1.5 angstroms. RTN3 is involved in the regulation of gene expression and cell signaling, and is thought to play a role in the development and maintenance of tissues with specific functions, such as eyes, hair, and nails.

One of the key functions of RTN3 is its role in the regulation of cell signaling. It is involved in the development and maintenance of tissues with specific functions, such as the development of hair and nails, and is thought to play a role in the regulation of cell signaling pathways that are involved in the development and maintenance of these tissues.

In addition to its role in cell signaling, RTN3 is also involved in the regulation of gene expression. It is a strong predictor of gene expression, and has been shown to play a role in the regulation of gene expression in various tissues and cells of the body.

The potential drug target status of RTN3 is supported by several studies. First, several studies have shown that RTN3 is a potential drug target for various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Second, several studies have shown that inhibition of RTN3 has been shown to be effective in treating various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

Finally, several studies have shown that RTN3 is a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. The levels of RTN3 have been shown to be elevated in various tissues and cells of the body, and have been used as a diagnostic marker for these diseases.

In conclusion, RTN3 is a protein that is involved in the regulation of gene expression and cell signaling, and is thought to play a role in the development and maintenance of tissues with specific functions, such as eyes, hair, and nails. Its potential as a drug target and biomarker is supported by several studies, and further research is needed to fully understand its role in the body.

Protein Name: Reticulon 3

Functions: May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition

More Common Targets

RTN4 | RTN4IP1 | RTN4R | RTN4RL1 | RTN4RL2 | RTP1 | RTP2 | RTP3 | RTP4 | RTP5 | RTRAF | RTTN | RUBCN | RUBCNL | RUFY1 | RUFY2 | RUFY3 | RUFY4 | RUNDC1 | RUNDC3A | RUNDC3A-AS1 | RUNDC3B | RUNX1 | RUNX1-IT1 | RUNX1T1 | RUNX2 | RUNX2-AS1 | RUNX3 | RUNX3-AS1 | RUSC1 | RUSC1-AS1 | RUSC2 | RUSF1 | RUVBL1 | RUVBL1-AS1 | RUVBL2 | RWDD1 | RWDD2A | RWDD2B | RWDD3 | RWDD3-DT | RWDD4 | RXFP1 | RXFP2 | RXFP3 | RXFP4 | RXRA | RXRB | RXRG | RXYLT1 | Ryanodine receptor | RYBP | RYK | RYR1 | RYR2 | RYR3 | RZZ complex | S100 Calcium Binding Protein | S100A1 | S100A10 | S100A11 | S100A11P1 | S100A12 | S100A13 | S100A14 | S100A16 | S100A2 | S100A3 | S100A4 | S100A5 | S100A6 | S100A7 | S100A7A | S100A7L2 | S100A7P1 | S100A8 | S100A9 | S100B | S100G | S100P | S100PBP | S100Z | S1PR1 | S1PR1-DT | S1PR2 | S1PR3 | S1PR4 | S1PR5 | SAA1 | SAA2 | SAA2-SAA4 | SAA3P | SAA4 | SAAL1 | SAC3D1 | SACM1L | SACS | SACS-AS1 | SAE1 | SAFB