IVNS1ABP: A drug target and biomarker for xenobiotic detoxification

Target Name: IVNS1ABP

NCBI ID: G10625

IVNS1ABP: A drug target and biomarker for xenobiotic detoxification

The Aryl hydrocarbon receptor (AhR) is a nuclear protein that plays a crucial role in the regulation of gene expression and is involved in the detoxification of xenobiotics, such as polycyclic aromatic hydrocarbons (PAHs). The AhR is also known as ARL10, and it is a key regulator of the xenobiotic response in the human body.

IVNS1ABP (Aryl hydrocarbon receptor-associated protein 3) is a protein that is expressed in human tissues and is highly conserved across various species. It is localized to the nuclear envelope and is considered to be a key regulator of gene expression in various tissues, including the lungs, gut, and liver.

IVNS1ABP functions as a protein that can interact with the AhR to regulate its activity. This interaction between IVNS1ABP and the AhR has important implications for the regulation of xenobiotics detoxification and the detoxification of environmental pollutants.

Drug targeting

IVNS1ABP is a drug target that can be targeted by small molecules. One of the most promising strategies for targeting IVNS1ABP is the use of inhibitors of its nuclear export, such as those that target the export of nuclear proteins out of the nucleus. This can lead to a decrease in the levels of IVNS1ABP in the cells, which can result in reduced xenobiotic detoxification.

Another approach to targeting IVNS1ABP is the use of inhibitors of its DNA binding. This can also lead to a decrease in the levels of IVNS1ABP in the cells, which can result in reduced xenobiotic detoxification.

Biomarker

IVNS1ABP can also be used as a biomarker for the diagnosis and monitoring of xenobiotic-induced toxicity. The levels of IVNS1ABP in tissues can be used as an indicator of the level of xenobiotic exposure and can be used to assess the effectiveness of different treatments for xenobiotic detoxification.

Conclusion

IVNS1ABP is a protein that plays a crucial role in the regulation of xenobiotic detoxification and the detoxification of environmental pollutants. Its interaction with the AhR makes it a potential drug target and a biomarker for the diagnosis and monitoring of xenobiotic-induced toxicity. Further research is needed to fully understand the role of IVNS1ABP in the regulation of xenobiotics and its potential as a drug and biomarker.

Protein Name: Influenza Virus NS1A Binding Protein

Functions: Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (By similarity). Protects cells from cell death induced by actin destabilization (By similarity). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (PubMed:16582008). In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (PubMed:25619834). Inhibits pre-mRNA splicing (in vitro) (PubMed:9696811)

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