Target Name: RTL8A
NCBI ID: G26071
Other Name(s): retrotransposon Gag like 8A | DKFZP564B147 | mammalian retrotransposon-derived 8A | SIRH6 | RTL8A variant 1 | family with sequence similarity 127 member B | Sushi-Ichi retrotransposon homolog 6 | Protein FAM127B | MAR8A | Retrotransposon Gag-like protein 8A | CXX1b | Retrotransposon Gag-like protein 8A (isoform 1) | FAM127B | Mammalian retrotransposon derived protein 8A | mammalian retrotransposon derived protein 8A | Retrotransposon Gag like 8A, transcript variant 1 | RTL8A_HUMAN | protein FAM127B

Understanding RTL8A: A Non-Coding RNA Molecule with Potential Therapeutic Applications

RTL8A, also known as retrotransposon Gag like 8A, is a non-coding RNA molecule that has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. In this article, we will explore the biology and potential therapeutic applications of RTL8A.

History of discovery

RTL8A was first identified in the late 1990s as a non-coding RNA molecule that was expressed in a variety of tissues and cells, including brain, heart, and testes. The molecule was characterized by its unique structure, which consisted of a core RNA molecule that was surrounded by a repeating array of seven tandem repeats of the variable region of the T7 RNA polymerase alpha subunit. This repeating pattern is known as a \"gag\" and is a hallmark of retrotransposons, which are a type of transposable DNA molecule that can integrate into the DNA of a host cell.

Several studies have since demonstrated that RTL8A plays a role in various cellular processes, including cell growth, differentiation, and RNA processing. In addition,RTL8A has been shown to be involved in the development and progression of a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

Potential therapeutic applications

RTL8A has several potential therapeutic applications, including as a drug target and biomarker.

As a drug target, RTL8A is a promising target for small molecule inhibitors that can inhibit the activity of the RNA polymerase II, which is a key enzyme that transcribes RNA from DNA in the cell. This is because the activity of this enzyme is critical for the growth, survival, and replication of cancer cells, as well as the development of neurodegenerative diseases.

In addition, RTL8A has been shown to play a role in the regulation of cellular processes that are important for the development of diseases, such as the regulation of cell death, cell proliferation, and tissue repair. This suggests that RTL8A may be a useful target for drugs that are aimed at preventing or treating these diseases.

As a biomarker, RTL8A has been shown to be a valuable diagnostic tool for a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. This is because the expression of RTL8A is often reduced in these diseases, and this can be used as a diagnostic target for these conditions.

RTL8A has also been shown to be a useful biomarker for tracking the efficacy of anti-cancer drugs in preclinical studies. This is because the expression of RTL8A is often reduced in cancer cells, and this can be used as a marker for the effectiveness of these drugs.

Conclusion

In conclusion, RTL8A is a non-coding RNA molecule that has been identified as a potential drug target and biomarker for various diseases. Further research is needed to fully understand the role of RTL8A in these conditions and to develop effective treatments. However, the potential of RTL8A as a drug target and biomarker is exciting and suggests that it may be a valuable addition to the arsenal of therapeutic agents for the treatment of these diseases.

Protein Name: Retrotransposon Gag Like 8A

More Common Targets

RTL8B | RTL8C | RTL9 | RTN1 | RTN2 | RTN3 | RTN4 | RTN4IP1 | RTN4R | RTN4RL1 | RTN4RL2 | RTP1 | RTP2 | RTP3 | RTP4 | RTP5 | RTRAF | RTTN | RUBCN | RUBCNL | RUFY1 | RUFY2 | RUFY3 | RUFY4 | RUNDC1 | RUNDC3A | RUNDC3A-AS1 | RUNDC3B | RUNX1 | RUNX1-IT1 | RUNX1T1 | RUNX2 | RUNX2-AS1 | RUNX3 | RUNX3-AS1 | RUSC1 | RUSC1-AS1 | RUSC2 | RUSF1 | RUVBL1 | RUVBL1-AS1 | RUVBL2 | RWDD1 | RWDD2A | RWDD2B | RWDD3 | RWDD3-DT | RWDD4 | RXFP1 | RXFP2 | RXFP3 | RXFP4 | RXRA | RXRB | RXRG | RXYLT1 | Ryanodine receptor | RYBP | RYK | RYR1 | RYR2 | RYR3 | RZZ complex | S100 Calcium Binding Protein | S100A1 | S100A10 | S100A11 | S100A11P1 | S100A12 | S100A13 | S100A14 | S100A16 | S100A2 | S100A3 | S100A4 | S100A5 | S100A6 | S100A7 | S100A7A | S100A7L2 | S100A7P1 | S100A8 | S100A9 | S100B | S100G | S100P | S100PBP | S100Z | S1PR1 | S1PR1-DT | S1PR2 | S1PR3 | S1PR4 | S1PR5 | SAA1 | SAA2 | SAA2-SAA4 | SAA3P | SAA4 | SAAL1