GFRA3: A GPCR Gene Involved in Signaling and Disease (G2676)

GFRA3: A GPCR Gene Involved in Signaling and Disease

GFRA3 (G protein-coupled receptor 3) is a protein that is expressed in many tissues throughout the body. It is a member of the G protein-coupled receptor (GPCR) family, which is a large family of transmembrane proteins that play an important role in cellular signaling. GFRA3 is one of the most well-studied GPCR genes, and it is known for its role in a variety of physiological processes, including sensory perception, neurotransmission, and hormone signaling.

GFRA3 is a GPCR that is characterized by its four transmembrane domains. The first transmembrane domain is a catalytic region that is involved in the formation of the G-protein-coupled receptor complex. The second transmembrane domain is a regulatory region that is involved in the regulation of gene expression. The third transmembrane domain is a carboxylic acid-rich region (CAR) that is involved in the formation of the protein-protein interaction (PPI) and is often involved in modulation by drugs. The fourth transmembrane domain is a cytoplasmic region that is involved in the intracellular signaling of GFRA3.

GFRA3 is expressed in many tissues throughout the body, including the brain, sensory neurons, and tissues of the endocrine system. It is involved in a variety of physiological processes, including the perception of touch, pain, and inflammation. GFRA3 is also involved in the regulation of neurotransmitter release from neurons and in the modulation of inflammation by immune cells.

GFRA3 is a potential drug target because of its involvement in a variety of physiological processes that can be targeted by drugs. For example, GFRA3 is involved in the regulation of pain perception, and drugs that can modulate GFRA3 activity may be effective in treating chronic pain. GFRA3 is also involved in the regulation of neurotransmission, and drugs that can modulate GFRA3 activity may be effective in treating neurological disorders. Additionally, GFRA3 is involved in the regulation of inflammation, and drugs that can modulate GFRA3 activity may be effective in treating inflammatory disorders.

GFRA3 is also a potential biomarker for a variety of diseases. For example, GFRA3 is involved in the regulation of pain perception, and changes in GFRA3 activity have been observed in a variety of neuropathic diseases, including chronic pain, neurodegenerative diseases, and pain-related disorders. Additionally, GFRA3 is involved in the regulation of neurotransmission, and changes in GFRA3 activity have been observed in a variety of neurotransmission disorders, including neuroimaging studies of depression and anxiety.

GFRA3 is a well-studied GPCR gene that is involved in a variety of physiological processes. It is potential drug target and biomarker for a variety of diseases. Further studies are needed to fully understand the role of GFRA3 in cellular signaling and its potential as a drug and biomarker.

Protein Name: GDNF Family Receptor Alpha 3

Functions: Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase

More Common Targets

GFRA4 | GFRAL | GFUS | GGA1 | GGA2 | GGA3 | GGACT | GGCT | GGCX | GGH | GGN | GGNBP1 | GGNBP2 | GGPS1 | GGT1 | GGT2P | GGT3P | GGT5 | GGT6 | GGT7 | GGT8P | GGTA1 | GGTLC1 | GGTLC2 | GGTLC3 | GH1 | GH2 | GHDC | GHITM | GHR | GHRH | GHRHR | GHRL | GHRLOS | GHSR | GID4 | GID8 | GIGYF1 | GIGYF2 | GIHCG | GIMAP1 | GIMAP1-GIMAP5 | GIMAP2 | GIMAP3P | GIMAP4 | GIMAP5 | GIMAP6 | GIMAP7 | GIMAP8 | GIMD1 | GIN1 | GINM1 | GINS complex | GINS1 | GINS2 | GINS3 | GINS4 | GIP | GIPC1 | GIPC2 | GIPC3 | GIPR | GIT1 | GIT2 | GJA1 | GJA10 | GJA1P1 | GJA3 | GJA4 | GJA5 | GJA8 | GJA9 | GJA9-MYCBP | GJB1 | GJB2 | GJB3 | GJB4 | GJB5 | GJB6 | GJB7 | GJC1 | GJC2 | GJC3 | GJD2 | GJD3 | GJD4 | GK | GK2 | GK3 | GK5 | GKAP1 | GKN1 | GKN2 | GKN3P | GLA | GLB1 | GLB1L | GLB1L2 | GLB1L3 | GLC1C