Identifying NT5C3A as A Potential Drug Target (G51251)

Target Name: NT5C3A

NCBI ID: G51251

Identifying NT5C3A as A Potential Drug Target

NT5C3A (PN-I), a non-coding RNA (ncRNA), has been identified as a potential drug target (PN) and biomarker in various diseases, including cancer. Its unique structure, function, and expression patterns make it an attractive target for the development of new therapies.

NT5C3A is a small non-coding RNA molecule that is expressed in various tissues and organs, including brain, heart, and muscle. It is characterized by a unique stem-loop structure and consists of 19 non-coding nucleotides. The PN5C3A RNA has been shown to play a role in various physiological processes, including cell growth, differentiation, and inflammation.

One of the key features of NT5C3A is its expression pattern. It is predominantly expressed in the brain, where it is found in high levels in the cerebral cortical tissue. It is also expressed in other tissues, including heart, muscle, and placenta. This selective expression pattern makes it an attractive target for the development of therapies that target specific tissues and organs.

In addition to its expression pattern, NT5C3A is also known for its unique function. It has been shown to regulate the activity of various enzymes, including the cell cycle enzyme, p21. This regulation of p21 activity is critical for the maintenance of the cell cycle and the regulation of cell growth and division.

The unique structure and function of NT5C3A make it an attractive target for the development of new therapies. Its small size and the fact that it is expressed in various tissues make it easy to target and manipulate. Additionally, its role in regulating the cell cycle and its selective expression in the brain makes it an ideal candidate for targeting therapies that are designed to modulate brain function.

NT5C3A has also been shown to play a role in the regulation of various signaling pathways, including the PI3K/Akt signaling pathway. This pathway is involved in the regulation of cell survival and growth, and its regulation by NT5C3A suggests that it may be a useful target for the development of therapies that target cancer cells.

In conclusion, NT5C3A is a unique and attractive target for the development of new therapies. Its small size, unique function, and selective expression in the brain make it an ideal candidate for targeting therapies that modulate brain function and cell growth. Further research is needed to fully understand the role of NT5C3A in various diseases and to develop effective therapies that target it.

Protein Name: 5'-nucleotidase, Cytosolic IIIA

Functions: Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP) (PubMed:24603684). CMP seems to be the preferred substrate (PubMed:15968458)

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