NUDC: A Potential Drug Target and Biomarker for Diseases (G10726)

Target Name: NUDC

NCBI ID: G10726

NUDC: A Potential Drug Target and Biomarker for Diseases

Nuclear Distribution Gene C Homolog (NUDC) is a gene that has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and psychiatric disorders. NUDC is a member of the nuclear distribution gene (NDG) family, which includes genes that are involved in the nuclear organization and delivery of intracellular proteins.

The NUDC gene was first identified in the late 1990s using transcriptomic studies. It is located on chromosome 16 and has been shown to be involved in the delivery of various proteins to the endoplasmic reticulum (ER), including proteins involved in cell signaling, cell adhesion, and neurotransmitter release.

NUDC has been shown to be involved in the development and progression of various diseases, including cancer. For example, studies have shown that NUDC is often overexpressed in cancer tissues and that inhibiting NUDC activity can be a potential therapeutic approach for cancer treatment. Additionally, NUDC has been shown to be involved in the regulation of cell growth and differentiation, which is often disrupted in cancer.

In addition to its involvement in cancer, NUDC has also been shown to be involved in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Studies have shown that NUDC is often overexpressed in the brains of individuals with these conditions and that inhibiting NUDC activity may be a potential therapeutic approach for these diseases.

NUDC has also been shown to be involved in the development of psychiatric disorders, such as depression and anxiety. Studies have shown that NUDC is often overexpressed in the brains of individuals with these conditions and that inhibiting NUDC activity may be a potential therapeutic approach for these disorders.

In conclusion, NUDC is a gene that has been shown to be involved in the delivery of various proteins to the endoplasmic reticulum and has been implicated in the development and progression of various diseases, including cancer, neurodegenerative diseases, and psychiatric disorders. Further research is needed to fully understand the role of NUDC in these diseases and to develop effective therapies that target NUDC activity.

Protein Name: Nuclear Distribution C, Dynein Complex Regulator

Functions: Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (PubMed:12852857, PubMed:12679384, PubMed:25789526). Necessary for cytokinesis and cell proliferation (PubMed:12852857, PubMed:12679384)

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