PFKFB2: A Potential Drug Target for Cellular Metabolism and Stress Regulation

Target Name: PFKFB2

NCBI ID: G5208

PFKFB2: A Potential Drug Target for Cellular Metabolism and Stress Regulation

Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2) is a protein that plays a crucial role in cellular metabolism. It is a key enzyme in the glycolytic pathway, which is the primary pathway for cellular energy production. PFKFB2 is responsible for breaking down glucose to produce energy in the form of ATP.

PFKFB2 is a protein that is expressed in almost all cell types in the human body. It is highly conserved, with only a small number of amino acid differences between its human and mouse counterparts. PFKFB2 is a 26 kDa protein that consists of 116 amino acids. It has a unique structure, with a catalytic active site and a substrate-binding site.

PFKFB2 is involved in the regulation of cellular metabolism, particularly in the context of glucose metabolism. It is a key enzyme in the glycolytic pathway, which is the primary pathway for cellular energy production. PFKFB2 is responsible for breaking down glucose to produce energy in the form of ATP. It does this by catalyzing the transfer of a phosphate group from its substrate, fructose-6-phosphate, to ADP. This transfer of a phosphate group allows ATP to be produced from ADP and Pi (phosphate inositol) using the energy from the reaction.

PFKFB2 is also involved in the regulation of cellular responses to stress, particularly in the context of inflammation. It is has been shown to play a role in the regulation of inflammation and has been linked to the production of pro-inflammatory cytokines.

PFKFB2 is a protein that has potential as a drug target or biomarker. Its role in cellular metabolism and its involvement in the regulation of cellular responses to stress make it an attractive target for drug development. There is a growing body of research that has identified potential drug compounds that can inhibit the activity of PFKFB2. These compounds have been shown to have a range of biological effects, including the inhibition of inflammation and the regulation of cellular metabolism.

In conclusion, PFKFB2 is a protein that plays a crucial role in cellular metabolism and has potential as a drug target or biomarker. Its unique structure and its involvement in the regulation of cellular responses to stress make it an attractive target for drug development. Further research is needed to fully understand the biology of PFKFB2 and its potential as a drug.

Protein Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

Functions: Synthesis and degradation of fructose 2,6-bisphosphate

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