SCT: A Protein Implicated in Cancer and Inflammation (G6343)

Target Name: SCT

NCBI ID: G6343

Other Name(s): SECR_HUMAN | prepro-secretin | secretin | Secretin

SCT: A Protein Implicated in Cancer and Inflammation

SCT (SECR-HUMAN) is a protein that is expressed in human tissues and has been shown to play a role in the development and progression of various diseases, including cancer. Because it is highly expressed in tissues and blood, it has a wide range of functions in the body The application prospects can be used as drug targets or biomarkers.

SCT is a glycoprotein that consists of two heavy chains and one light chain. It is expressed in various tissues and organs of the human body, including the liver, lung, kidney, and heart. SCT has been shown to be involved in many important biological processes in the body, including cell signaling, inflammation, and immune response.

One of the most significant functions of SCT is its role in cancer development. Many studies have shown that high levels of SCT are associated with the development and progression of various cancers, including breast, lung, and ovarian cancers. Additionally, SCT has been shown to promote the growth and metastasis of cancer cells. Therefore, targeting SCT with drugs or other therapeutic approaches may be an effective way to treat or prevent these cancers.

Another potential application of SCT is as a biomarker for disease diagnosis and monitoring. Because SCT is expressed in various tissues and organs, it may be a useful marker for tracking the progress of diseases, such as cancer, or for diagnosing diseases at early stages. Additionally, SCT may be used as a biomarker to monitor the effectiveness of drugs or other therapeutic approaches.

SCT has also been shown to play a role in inflammation and immune response. In response to infection or damage, SCT is often activated and has been shown to play a key role in the immune response. Additionally, SCT has been shown to regulate the production of pro-inflammatory cytokines, which can contribute to inflammation and tissue damage.

In conclusion, SCT is a protein that has been shown to be involved in a wide range of important biological processes in the body. Its potential as a drug target or biomarker makes it an attractive target for further research and development. Further studies are needed to fully understand the role of SCT in disease and to develop effective treatments or diagnostic tools based on it.

Protein Name: Secretin

Functions: Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis (PubMed:25332973). Exerts its biological effects by binding to secretin receptor (SCTR), a G-protein coupled receptor expressed in the basolateral domain of several cells (PubMed:25332973). Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content (By similarity). Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). Production of bicarbonate is essential to neutralize the pH and ensure no damage is done to the small intestine by the gastric acid (By similarity). In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation (Probable). Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation (By similarity). Also able to stimulate lipolysis in white adipocytes (By similarity). Also plays an important role in cellular osmoregulation: released into the systemic circulation in response to hyperosmolality and acts at different levels in the hypothalamus, pituitary and kidney to regulate water homeostasis (By similarity). Also plays a role in the central nervous system, possibly by acting as a neuropeptide hormone: required for hippocampal synaptic function and neural progenitor cells maintenance (By similarity)

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