ZMIR: A Potential Drug Target and Biomarker for Diseases (G83637)
ZMIR: A Potential Drug Target and Biomarker for Diseases
ZMIZ2 (ZMIZ2_HUMAN), a gene product of the zebrafish species, has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. ZMIZ2 is a gene that encodes a protein known as zebrafish mitochondrial intracellular resistance (ZMIR), which plays a crucial role in the regulation of mitochondrial function and metabolism.
The ZMIR protein is a key component of the mitochondrial inner membrane, which is the boundary between the mitochondria and the cytoplasm. The ZMIR protein helps to maintain the stability of the mitochondrial inner membrane and is involved in various cellular processes, including energy metabolism, cell signaling, and stress resistance.
Studies have shown that alterations in ZMIR levels or function have been implicated in the development and progression of various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. For example, ZMIR has been shown to be overexpressed in various cancer types, including breast, ovarian, and colorectal cancers. Additionally, ZMIR has been linked to neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease.
In addition to its potential as a drug target, ZMIR has also been identified as a potential biomarker for various diseases. The ZMIR protein is expressed in various tissues and cells, including cancer cells, neurons, and glial cells in the central nervous system. Therefore, it may be a useful biomarker for the diagnosis and monitoring of various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases.
One of the challenges in studying ZMIR is its expression and function in different organisms and tissues. However, researchers have been able to study ZMIR in various models, including zebrafish, mouse, and human samples. For example, studies have shown that ZMIR is expressed and functions similarly in zebrafish and mouse models of cancer, neurodegenerative disorders, and autoimmune diseases.
In addition to its potential as a drug target and biomarker, ZMIR also has potential as a research tool for studying cellular and molecular mechanisms underlying disease. For example, researchers have used ZMIR to study the effects of drugs on mitochondrial function and metabolism, as well as the role of the ZMIR protein in modulating cellular signaling pathways.
Overall, ZMIR is a promising drug target and biomarker for various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. Further research is needed to fully understand its role and potential as a therapeutic agent.
Protein Name: Zinc Finger MIZ-type Containing 2
Functions: Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors
More Common Targets
ZMPSTE24 | ZMYM1 | ZMYM2 | ZMYM3 | ZMYM4 | ZMYM4-AS1 | ZMYM5 | ZMYM6 | ZMYND10 | ZMYND11 | ZMYND12 | ZMYND15 | ZMYND19 | ZMYND8 | ZNF10 | ZNF100 | ZNF101 | ZNF106 | ZNF107 | ZNF112 | ZNF114 | ZNF117 | ZNF12 | ZNF121 | ZNF124 | ZNF131 | ZNF132 | ZNF133 | ZNF134 | ZNF135 | ZNF136 | ZNF137P | ZNF138 | ZNF14 | ZNF140 | ZNF141 | ZNF142 | ZNF143 | ZNF146 | ZNF148 | ZNF154 | ZNF155 | ZNF157 | ZNF16 | ZNF160 | ZNF165 | ZNF169 | ZNF17 | ZNF174 | ZNF175 | ZNF177 | ZNF18 | ZNF180 | ZNF181 | ZNF182 | ZNF184 | ZNF185 | ZNF189 | ZNF19 | ZNF195 | ZNF197 | ZNF2 | ZNF20 | ZNF200 | ZNF202 | ZNF204P | ZNF205 | ZNF205-AS1 | ZNF207 | ZNF208 | ZNF209P | ZNF211 | ZNF212 | ZNF213 | ZNF213-AS1 | ZNF214 | ZNF215 | ZNF217 | ZNF219 | ZNF22 | ZNF22-AS1 | ZNF221 | ZNF222 | ZNF223 | ZNF224 | ZNF225 | ZNF225-AS1 | ZNF226 | ZNF227 | ZNF229 | ZNF23 | ZNF230 | ZNF232 | ZNF232-AS1 | ZNF233 | ZNF234 | ZNF235 | ZNF236 | ZNF236-DT | ZNF239
