Target Name: NSUN6
NCBI ID: G221078
Other Name(s): NSUN6_HUMAN | nucleolar protein (NOL1/NOP2/sun) and PUA domains 1 | ARL5B-AS1 | NSUN6 variant 1 | tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 | NOP2/Sun RNA methyltransferase 6 | FLJ23743 | NOL1/NOP2/Sun and PUA domain-containing protein 1 | ARL5B antisense RNA 1 | NOP2/Sun domain family, member 6 | NOP2/Sun RNA methyltransferase 6, transcript variant 1 | NOPD1 | TRNA (cytosine(72)-C(5))-methyltransferase NSUN6 (isoform 1) | Nucleolar protein (NOL1/NOP2/sun) and PUA domains 1 | OTTHUMP00000019261 | 4933414E04Rik | NOL1/NOP2/Sun domain family 6 | Putative methyltransferase NSUN6 | putative methyltransferase NSUN6 | NOP2/Sun RNA methyltransferase family member 6 | NOL1/NOP2/Sun domain family, member 6 | NOL1/NOP2/Sun domain family member 6 | OTTHUMP00000045208

Unraveling NSUN6: The Potential Drug Target and Biomarker

The Potential Drug Target or Biomarker NSUN6: Unraveling the Complex Structure and Functions of a Negatively Expressed Uni-Transcribed RNA

Uni-transcribed RNA (uTR) is a non-coding RNA molecule that plays a vital role in regulating gene expression. One of the well-known uTRs is the neurodevelopmental regulator, NSUN6 (NSUN6_HUMAN). This gene has been implicated in the pathogenesis of various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. The study of NSUN6 and its associated proteins has the potential to unravel the underlying mechanisms of these disorders and lead to new therapeutic approaches.

NSUN6: Structure and Functions

The NSUN6 gene is located on chromosome 11q22 and encodes a 21-kb RNA molecule with 11 exons. The RNA molecule has a highly conserved structure, with a single open reading frame (ORF) and a single start codon.

The NSUN6 ORF consists of the following sequence:

GAAATGACCTAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGAT

Protein Name: NOP2/Sun RNA Methyltransferase 6

Functions: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in tRNA(Thr)(TGT) and tRNA(Cys)(GCA) (PubMed:26160102, PubMed:27703015, PubMed:28531330). In vitro also methylates tRNA(Thr)(AGT) (PubMed:27703015, PubMed:26160102). Methylation requires, in the acceptor stem region, the presence of the 3'-CCA terminus, the target site C72, the discriminator base U73, and the second and third base pairs (2:71 and 3:70) in the tRNA substrates (PubMed:26160102, PubMed:27703015)

More Common Targets

NSUN7 | NT5C | NT5C1A | NT5C1B | NT5C1B-RDH14 | NT5C2 | NT5C3A | NT5C3AP1 | NT5C3B | NT5CP2 | NT5DC1 | NT5DC2 | NT5DC3 | NT5DC4 | NT5E | NT5M | NTAN1 | NTAQ1 | NTF3 | NTF4 | NTHL1 | NTM | NTMT1 | NTMT2 | NTN1 | NTN3 | NTN4 | NTN5 | NTNG1 | NTNG2 | NTPCR | NTRK1 | NTRK2 | NTRK3 | NTRK3-AS1 | NTS | NTSR1 | NTSR2 | NuA4 histone acetyltransferase (HAT) complex | NUAK Family SNF1-like Kinase (nonspcified subtype) | NUAK1 | NUAK2 | NUB1 | NUBP1 | NUBP2 | NUBPL | NUCB1 | NUCB2 | NUCKS1 | Nuclear factor interleukin-3-regulated protein-like | Nuclear factor of activated T-cells | Nuclear Pore Complex | Nuclear Receptor ROR | Nuclear transcription factor Y | Nucleoside Diphosphate Kinase (NDK) | Nucleosome Remodeling and Deacetylase (NuRD) Complex | Nucleosome-remodeling factor complex (NURF) | NUDC | NUDCD1 | NUDCD2 | NUDCD3 | NUDCP2 | NUDT1 | NUDT10 | NUDT11 | NUDT12 | NUDT13 | NUDT14 | NUDT15 | NUDT15P1 | NUDT16 | NUDT16-DT | NUDT16L1 | NUDT16L2P | NUDT17 | NUDT18 | NUDT19 | NUDT2 | NUDT21 | NUDT22 | NUDT3 | NUDT4 | NUDT4B | NUDT4P2 | NUDT5 | NUDT6 | NUDT7 | NUDT8 | NUDT9 | NUDT9P1 | NUF2 | NUFIP1 | NUFIP2 | NUGGC | NUMA1 | NUMB | NUMBL | NUP107 | Nup107-160 complex | NUP133