Cytomegalovirus & HIV: Nucleoside Transferase 5'N as A Drug Target & Biomarker

Target Name: NT5C2

NCBI ID: G22978

Cytomegalovirus & HIV: Nucleoside Transferase 5'N as A Drug Target & Biomarker

Nucleoside phosphotransferase 5'N (NT5C2) is a protein that plays a crucial role in the replication process of many viruses, including human immunodeficiency virus (HIV), hepatitis B virus (HBV), and cytomegalovirus (HCV) . The cytosolic nucleoside phosphotransferase 5'N is an enzyme that is involved in the transfer of nucleosides from the 5'-end of a DNA strand to the 3'-end of the strand during the process of DNA replication.

NT5C2 is a member of the nucleoside transferase family 2, which includes enzymes that transfer nucleosides from the 5'-end to the 3'-end during DNA replication, transcription, and translation. The nucleoside transferase family 2 includes three subfamilies, including the A , B, and C subfamilies. The A subfamily includes enzymes that transfer nucleosides from the 5'-end to the 3'-end during DNA replication, while the B subfamily includes enzymes that transfer nucleosides from the 5'-end to the 3' -end during transcription. The C subfamily includes enzymes that transfer nucleosides from the 5'-end to the 3'-end during translation.

NT5C2 is a 26 kDa protein that is expressed in a variety of cell types, including T cells, B cells, and dendritic cells. The protein has a molecular weight of 62 kDa and a calculated pI of 6.5. NT5C2 is a monomer that has a single transmembrane domain and a nucleotide-binding oligomerization domain (NBD) that is responsible for binding nucleosides.

The function of NT5C2 is to transfer nucleosides from the 5'-end to the 3'-end during DNA replication. During DNA replication, the double helix is 鈥嬧?媠eparated and the two primers are used to repair the double helix. The 5'-end of the double helix is 鈥嬧?媤here the first nucleoside is added, and the 3'-end is where the last nucleoside is added. NT5C2 is involved in the transfer of nucleosides from the 5'-end to the 3'-end during this process.

NT5C2 is a critical enzyme for the replication of many viruses. For example, NT5C2 is involved in the replication of HIV-1, the most deadly form of the human immunodeficiency virus (HIV). During the replication of HIV-1, NT5C2 is responsible for transferring the nucleoside G from the 5'-end of the double helix to the 3'-end.

NT5C2 is also involved in the replication of HBV, the virus that causes hepatitis B. During the replication of HBV, NT5C2 is responsible for transferring the nucleoside A from the 5'-end of the double helix to the 3'-end.

In addition to its role in virus replication, NT5C2 has also been shown to have potential as a drug target or biomarker. For example, studies have shown that NT5C2 can be inhibited by a variety of small molecules, including inhibitors of nucleoside transfer, DNA- protein interactions, and protein-protein interactions.

NT5C2 has also been shown to be a potential biomarker for monitoring the effectiveness of antiviral drugs in treating HIV and HBV. For example, studies have shown that the levels of NT5C2 in the plasma of individuals treated with antiviral drugs are often reduced compared to those who are not treated. This suggests that NT5C2

Protein Name: 5'-nucleotidase, Cytosolic II

Functions: Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates (PubMed:1659319, PubMed:9371705, PubMed:10092873, PubMed:12907246). In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine (PubMed:1659319, PubMed:9371705). Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP (PubMed:1659319, PubMed:9371705, PubMed:10092873, PubMed:12907246). Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency (PubMed:1659319, PubMed:9371705). Through these activities regulates the purine nucleoside/nucleotide pools within the cell (PubMed:1659319, PubMed:9371705, PubMed:10092873, PubMed:12907246)

More Common Targets