GPR26: A GPCR in Cellular Signaling and Therapeutic Targets (G2849)
GPR26: A GPCR in Cellular Signaling and Therapeutic Targets
G-protein coupled receptor 26 (GPR26) is a protein that plays a crucial role in cellular signaling. It is a member of the G-protein-coupled receptor (GPCR) family, which is a large family of transmembrane proteins that play a key role in cellular signaling. GPR26 is widely expressed in various tissues and is involved in various physiological processes, including sensory perception, neurotransmission, and hormone signaling.
GPR26 is a GPCR that is characterized by the presence of a catalytic alpha-helices, a transmembrane segment, and a unique N-terminal region that contains a putative extracellular domain. The alpha-helices are involved in the formation of the GPCR structure and are responsible for the G protein-coupling. The transmembrane segment is responsible for the delivery of the protein to the cell surface and is involved in the interaction with various signaling molecules. The unique N-terminal region is involved in the interaction with other proteins and is thought to play a role in GPR26 function.
GPR26 is involved in various physiological processes, including sensory perception, neurotransmission, and hormone signaling. For example, GPR26 is involved in the sense of touch and pressure. When the skin is stimulated with a hard or soft object, GPR26 is activated and sends signals to the brain, resulting in the sensation of touch. GPR26 is also involved in neurotransmission, including the transmission of pain signals from the body to the brain.
GPR26 is also involved in hormone signaling, including the regulation of sexual behavior in humans. For example, GPR26 is known to be involved in the regulation of sexual desire and is thought to play a role in the development of sexual behavior in humans. GPR26 is also involved in the regulation of mood and anxiety, including the regulation of anxiety disorders.
GPR26 is a potential drug target and may be a useful biomarker for the diagnosis and treatment of various psychiatric and neurological disorders. For example, GPR26 may be a target for treating anxiety disorders, as it is involved in the regulation of anxiety signals in the brain. GPR26 may also be a target for treating depression, as it is involved in the regulation of mood and anxiety.
In addition to its potential therapeutic uses, GPR26 is also a valuable research tool for studying the molecular mechanisms of GPCR signaling. The GPCR signaling pathway is complex and the role of GPR26 in this pathway is not yet fully understood. By studying the function of GPR26, researchers can gain insights into the molecular mechanisms that underlie GPCR signaling and may uncover new targets for therapeutic intervention.
Overall, GPR26 is a GPCR that plays a crucial role in cellular signaling. Its wide expression and various functions make it an attractive target for therapeutic intervention. Further research is needed to fully understand the role of GPR26 in GPCR signaling and to develop new treatments for various psychiatric and neurological disorders.
Protein Name: G Protein-coupled Receptor 26
Functions: Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP
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GPR27 | GPR3 | GPR31 | GPR32 | GPR33 | GPR34 | GPR35 | GPR37 | GPR37L1 | GPR39 | GPR4 | GPR42 | GPR45 | GPR50 | GPR52 | GPR55 | GPR6 | GPR61 | GPR62 | GPR63 | GPR65 | GPR68 | GPR75 | GPR75-ASB3 | GPR78 | GPR79 | GPR82 | GPR83 | GPR84 | GPR84-AS1 | GPR85 | GPR87 | GPR88 | GPR89A | GPR89B | GPRACR | GPRASP1 | GPRASP2 | GPRASP3 | GPRC5A | GPRC5B | GPRC5C | GPRC5D | GPRC5D-AS1 | GPRC6A | GPRIN1 | GPRIN2 | GPRIN3 | GPS, PLAT and transmembrane domain-containing protein | GPS1 | GPS2 | GPS2P1 | GPSM1 | GPSM2 | GPSM3 | GPT | GPT2 | GPX1 | GPX1P1 | GPX2 | GPX3 | GPX4 | GPX5 | GPX6 | GPX7 | GPX8 | GRAMD1A | GRAMD1B | GRAMD1C | GRAMD2A | GRAMD2B | GRAMD4 | GRAMD4P2 | GRAMD4P5 | GRAMD4P7 | Granzyme | GRAP | GRAP2 | GRAPL | GRAPL-AS1 | GRASLND | GRB10 | GRB14 | GRB2 | GRB7 | GREB1 | GREB1L | GREM1 | GREM1-AS1 | GREM2 | GREP1 | GRHL1 | GRHL2 | GRHL3 | GRHL3-AS1 | GRHPR | GRIA1 | GRIA2 | GRIA3 | GRIA4
