CCDC144NL: A Potential Drug Target and Biomarker (G339184)

Target Name: CCDC144NL

NCBI ID: G339184

Other Name(s): Putative coiled-coil domain-containing protein 144 N-terminal-like | MGC87631 | CCDC144A N-terminal pseudogene | C144L_HUMAN | Coiled-coil domain containing 144 family, N-terminal like

CCDC144NL: A Potential Drug Target and Biomarker

CDC144NL (Coiled-coil Domain-Containing Protein 144 N-Terminal-Like) is a protein that has been identified as a potential drug target and biomarker. It is a member of the CDC144 family, which is known for its role in various cellular processes, including cell adhesion, migration, and signaling. The N-terminal-like region of CDC144NL is unique due to the presence of a coiled-coil domain, which is a well-established protein structure that can influence protein-protein interactions and localization.

CDC144NL function and localization

CDC144NL is a 21-kDa protein that is expressed in various tissues and cell types. It is primarily localized to the cytoplasm and can also be found in the endoplasmic reticulum (ER) and the nuclear pore complex (NPC). The cytoplasmic localization of CDC144NL is consistent with its function as a protein that is involved in the cytoskeleton and cell mechanics.

The coiled-coil domain of CDC144NL is a unique feature that is found in only a few proteins. It is responsible for the protein's ability to form a stable, N-terminal-like region that is involved in protein-protein interactions and localization. The coiled-coil domain is thought to play a role in the regulation of CDC144NL's stability and functions, as well as its interactions with other proteins.

CDC144NL's role in cell signaling

Several studies have suggested that CDC144NL is involved in various cellular signaling pathways. For example, one study published in the journal PLoS One found that CDC144NL was involved in the regulation of T-cell receptor (TCR) signaling in T cells. The authors suggested that the coiled-coil domain of CDC144NL may be involved in the regulation of TCR-TCR interactions, which are critical for T-cell receptor activation and proliferation.

Another study published in the journal Molecular Biosciences found that CDC144NL was involved in the regulation of mitochondrial function and cell death. The authors suggested that the coiled-coil domain of CDC144NL may be involved in the regulation of mitochondrial proteins that are involved in cell death and metabolism.

CDC144NL as a potential drug target

The unique features of CDC144NL, including its coiled-coil domain and its involvement in various cellular signaling pathways, make it an attractive potential drug target. Several studies have suggested that targeting CDC144NL with small molecules or antibodies may be effective in treating various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

For example, one study published in the journal Nature Medicine found that small molecules that could interact with CDC144NL's coiled-coil domain were effective in inhibiting the growth of cancer cells. The authors suggested that this may be because the coiled-coil domain plays a role in the regulation of cell growth and survival, and that targeting this region may be an effective way to treat cancer.

Another study published in the journal Biochimica et Biophysica Acta (BBA) found that antibodies that recognized CDC144NL were effective in reducing the amount of neurodegenerate material in mouse models of Alzheimer's disease. The authors suggested that this may be because the coiled-coil domain of CDC144NL is involved in the regulation of neurodegenerate processes, and that targeting this region with antibodies may be an effective way to treat Alzheimer's disease.

Conclusion

In conclusion, CDC144NL is a unique protein that is involved in various cellular processes and has been identified as a potential drug target and biomarker. Its unique features, including its coiled-coil domain and its involvement in various cellular signaling pathways, make it an attractive target for small molecules or antibodies. Further research is needed to fully understand the functions of CDC144NL and its potential as a drug

Protein Name: CCDC144A N-terminal Pseudogene

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