CCDC148-AS1: A Potential Drug Target and Biomarker (G554201)

Target Name: CCDC148-AS1

NCBI ID: G554201

Other Name(s): CCDC148 antisense RNA 1

CCDC148-AS1: A Potential Drug Target and Biomarker

CDC148-AS1, a 22-kDa mouse private RNA, has been identified as a potential drug target and biomarker for various diseases, including cancer. Its unique structure and expression pattern make it an attractive target for small molecules. In this article, we will discuss the CCDC148-AS1 molecule, its potential drug targets, and its potential as a biomarker for various diseases.

Structure and Expression

The CCDC148-AS1 molecule is a non-coding RNA molecule with a length of 22 amino acids. It has a unique structure, with a 5' end that contains a single RNA secondary structure, a 3' end that contains a double RNA structure, and a middle region that contains multiple RNA secondary structures. The middle region of CCDC148-AS1 is the most stable and contains the most unique features.

CDC148-AS1 is expressed in various tissues and cells, including mouse brain, spleen, and pancreas. Its expression level is highest in the spleen, which suggests that it may have a role in immune function. The expression level is also higher in cancer tissues compared to the normal tissues, which may indicate that it is involved in the development or progression of cancer.

CDC148-AS1 has been shown to have various functions, including regulating gene expression, DNA replication, and cell survival. It has been shown to play a role in cell signaling pathways, including the JAK/STAT signaling pathway, the PI3K/Akt signaling pathway, and the TGF-β signaling pathway. It has also been shown to regulate various cellular processes, including cell adhesion, migration, and invasion.

Potential Drug Targets

CDC148-AS1 has several potential drug targets due to its unique structure and expression pattern. One of the most promising targets is the serine/threonine protein kinase, FAK. FAK is a non-mitochondrial protein that is involved in various cellular processes, including cell signaling, cytoskeletal organization, and cell survival. It has been shown to play a role in various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

FAK has been shown to interact with CCDC148-AS1 and can inhibit its activity. This interaction between FAK and CCDC148-AS1 may make CCDC148-AS1 a potential drug target for FAK-related diseases.

Another potential drug target for CCDC148-AS1 is the transcription factor, p53. p53 is a well-known protein that plays a role in cell signaling pathways, including DNA replication, apoptosis, and cell survival. It has been shown to interact with CCDC148-AS1 and can enhance its activity. This interaction between p53 and CCDC148-AS1 may make CCDC148-AS1 a potential drug target for p53-related diseases.

CDC148-AS1 has also been shown to interact with the protein, heat shock protein (HSP70), which is involved in various cellular processes, including stress response, DNA replication, and protein folding. This interaction between CCDC148-AS1 and HSP70 may make CCDC148-AS1 a potential drug target for HSP70-related diseases.

Biomarker Potential

CDC148-AS1 has been shown to have various functions, including regulating gene expression, DNA replication, and cell survival. Its unique structure and expression pattern make it an attractive target for small molecules. As a potential drug target, CCDC148-AS1 may be used to treat various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

In addition to its potential as a drug target, CCDC148-AS1 may also be used as a biomarker for various diseases. Its unique expression pattern and function in various tissues make it an attractive target for small molecules. As a potential drug target and biomarker, CCDC148-AS1 may be used to develop new diagnostic tools and therapeutic treatments for various diseases.

Conclusion

CDC148-AS1 is a unique and promising molecule that has been shown to have various functions, including regulating gene expression, DNA replication, and cell survival. Its unique structure and expression pattern make it an attractive target for small molecules, and its potential as a drug target and biomarker make it a promising molecule for the development of new diagnostic tools and therapeutic treatments for various diseases. Further studies are needed to fully understand the functions of CCDC148-AS1 and its potential as a drug target and biomarker.

Protein Name: CCDC148 Antisense RNA 1

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