Target Name: GPR15LG
NCBI ID: G387695
Other Name(s): GPR15L | colon-derived SUSD2 binding factor | Protein GPR15L | RLLV1833 | secreted protein C10orf99 | antimicrobial peptide-57 | UNQ1833 | protein GPR15 ligand | Antimicrobial peptide with 57 amino acid residues | Colon-derived SUSD2 binding factor | AP57 | G protein-coupled receptor 15 ligand | Putative uncharacterized protein C10orf99 | Protein GPR15LG | GP15L_HUMAN | Antimicrobial peptide-57 | anti-microbial peptide with 57 amino acid residues | antimicrobial peptide with 57 amino acid residues | CSBF | AP-57 | C10orf99 | Protein GPR15 ligand

GPR15LG: A GPCR Targeted for Small Molecules and Diseases

GPR15LG, also known as GPR15L8, is a G protein-coupled receptor (GPCR) that is expressed in various tissues, including the brain, heart, and gastrointestinal tract. It is a potential drug target and has been identified as a biomarker for various diseases , including cancer, neurodegenerative diseases, and chronic pain.

GPR15LG is a member of the GPCR family, which is a large superfamily of transmembrane proteins that play a critical role in cellular signaling. GPCR family members are involved in various physiological processes, including sensory perception, neurotransmission, and hormone signaling.

GPR15LG is a 19-kDa protein that is expressed in the brain, heart, and gastrointestinal tract. It is highly conserved, with a calculated pI of 11.95 and a predicted transmembrane potential of 200 mV. GPR15LG is localized to the end of the longest N -terminus and has a unique N-terminal region that consists of a 尾-sheet and a 纬-helices.

GPR15LG has been shown to play a critical role in various physiological processes, including neurotransmission and pain perception. GPR15LG is involved in neurotransmission, specifically in the regulation of neurotransmitter release and receptor function. It has been shown to interact with various neurotransmitters, including dopamine, GABA, and endogenous opioids.

In addition to its role in neurotransmission, GPR15LG has also been shown to be involved in pain perception. GPR15LG is known to play a critical role in the regulation of pain signaling, as it has been shown to modulate the release of pain-related neurotransmitters.

GPR15LG has also been shown to be involved in various signaling pathways, including the TGF-β pathway. This pathway is involved in the regulation of cell growth, differentiation, and survival, and is a key factor in the development and progression of many diseases, including cancer.

GPR15LG has also been shown to be involved in the regulation of inflammation. It has been shown to play a critical role in the regulation of pro-inflammatory responses and has been shown to have anti-inflammatory effects.

GPR15LG is also a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and chronic pain. It has also been shown to be involved in the regulation of cancer cell growth and has been shown to have anti-cancer effects. to be involved in the regulation of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

In addition to its potential therapeutic uses, GPR15LG is also a potential drug target. Its unique structure and various interactions with neurotransmitters and signaling pathways make it an attractive target for small molecules. Additionally, its involvement in various physiological processes makes it a potential target for drugs that are used to treat various diseases, including cancer, neurodegenerative diseases, and chronic pain.

In conclusion, GPR15LG is a GPCR that is involved in various physiological processes and has been shown to play a critical role in neurotransmission, pain perception, and signaling pathways. Its unique structure and various interactions with neurotransmitters make it an attractive target for small molecules, and its involvement in various diseases makes it a potential drug target. Further research is needed to fully understand the role of GPR15LG in various physiological processes and its potential as a drug target.

Protein Name: G Protein-coupled Receptor 15 Ligand

Functions: Highly cationic protein that has multiple functions. Acts as a chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G-protein coupled receptor GPR15 (PubMed:28900043, PubMed:28936214). May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). May regulate keratinocyte proliferation (PubMed:29872130). In addition, through activation of Mas-related G protein-coupled receptors (MRGPRs) contributes to pruritogenesis by activating itch-selective sensory neurons and mast cells degranulation (PubMed:35704588)

More Common Targets

GPR160 | GPR161 | GPR162 | GPR17 | GPR171 | GPR173 | GPR174 | GPR176 | GPR179 | GPR18 | GPR180 | GPR182 | GPR183 | GPR19 | GPR199P | GPR20 | GPR21 | GPR22 | GPR25 | GPR26 | GPR27 | GPR3 | GPR31 | GPR32 | GPR33 | GPR34 | GPR35 | GPR37 | GPR37L1 | GPR39 | GPR4 | GPR42 | GPR45 | GPR50 | GPR52 | GPR55 | GPR6 | GPR61 | GPR62 | GPR63 | GPR65 | GPR68 | GPR75 | GPR75-ASB3 | GPR78 | GPR79 | GPR82 | GPR83 | GPR84 | GPR84-AS1 | GPR85 | GPR87 | GPR88 | GPR89A | GPR89B | GPRACR | GPRASP1 | GPRASP2 | GPRASP3 | GPRC5A | GPRC5B | GPRC5C | GPRC5D | GPRC5D-AS1 | GPRC6A | GPRIN1 | GPRIN2 | GPRIN3 | GPS, PLAT and transmembrane domain-containing protein | GPS1 | GPS2 | GPS2P1 | GPSM1 | GPSM2 | GPSM3 | GPT | GPT2 | GPX1 | GPX1P1 | GPX2 | GPX3 | GPX4 | GPX5 | GPX6 | GPX7 | GPX8 | GRAMD1A | GRAMD1B | GRAMD1C | GRAMD2A | GRAMD2B | GRAMD4 | GRAMD4P2 | GRAMD4P5 | GRAMD4P7 | Granzyme | GRAP | GRAP2 | GRAPL | GRAPL-AS1