GPR173: A Potential Drug Target and Biomarker (G54328)

GPR173: A Potential Drug Target and Biomarker

G protein-coupled receptors (GPCRs) are a family of transmembrane proteins that play a crucial role in cellular signaling. GPR173 is a GPCR that has been identified as a potential drug target and biomarker. This protein is located in the brain and is involved in various signaling pathways, including pain perception, anxiety, and depression.

GPR173 is a small molecule that can interact with various molecules, including small molecules, peptides, and proteins. This protein has been shown to play a role in modulating pain perception and anxiety in animal models. For example, studies have shown that GPR173 is involved in the modulation of pain sensitivity and that it can interact with opioids to reduce pain.

In addition to its role in pain perception, GPR173 has also been shown to be involved in the modulation of anxiety and depression. Studies have shown that GPR173 is involved in the modulation of anxiety-like behavior in animal models and that it can interact with molecules involved in anxiety regulation, such as the neurotransmitter GABA.

GPR173 is also involved in the modulation of social behavior, including trust and bonding. Studies have shown that GPR173 is involved in the modulation of social interactions in animals and that it can interact with molecules involved in social behavior, such as the neurotransmitter dopamine.

GPR173 has also been shown to play a role in the regulation of sleep and circadian rhythm. Studies have shown that GPR173 is involved in the modulation of sleep behavior in animals and that it can interact with molecules involved in circadian rhythm, such as the neurotransmitter melatonin.

GPR173 is a small molecule that can interact with various molecules, including small molecules, peptides, and proteins. This protein has been shown to play a role in modulating pain perception, anxiety, and depression, as well as social behavior and sleep. As a result, GPR173 is a potential drug target and biomarker for various psychiatric and neurological disorders.

In conclusion, GPR173 is a GPCR that has been shown to play a role in various signaling pathways, including pain perception, anxiety, and depression. As a potential drug target and biomarker, GPR173 is a promising target for the development of new treatments for psychiatric and neurological disorders. Further research is needed to fully understand the role of GPR173 in cellular signaling and its potential as a drug target.

Protein Name: G Protein-coupled Receptor 173

Functions: Is a receptor for the SMIM20 derived peptides Phoenixin-14 and Phoenixin-20 (By similarity). It mediates the Phoenixin-14 and Phoenixin-20 augmentation of gonadotropin-releasing hormone (GNRH) signaling in the hypothalamus and pituitary gland (By similarity). In the ovary, it mediates the effects of Phoenixin-14 and Phoenixin-20 induced granulosa cell proliferation during follicular growth (PubMed:30933929)

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