PDE3B: Key Enzyme in Hydrophobic-Hydrophilic Balance Process (G5140)

Target Name: PDE3B

NCBI ID: G5140

PDE3B: Key Enzyme in Hydrophobic-Hydrophilic Balance Process

Proteins with the molecular weight of 300 kDa (kDa) or greater are called large proteins or macromolecules. These molecules are involved in various cellular processes such as signaling, structure, and function. One such protein is PDE3B (Protein Disulfide Isomerization Enzyme 3B), which is a key enzyme in the Hydrophobic-Hydrophilic Balance process that is essential for cell signaling. PDE3B is a protein that is expressed in most tissues and cells of the human body, making it an attractive drug target or biomarker.

PDE3B is a member of the PDE family, which includes proteins that are involved in the regulation of protein-protein interactions, protein stability, and signaling pathways. The PDE family is characterized by the presence of a catalytic domain and a transmembrane region. PDE3B has a unique structure, as it consists of a catalytic domain that is divided into two distinct regions: the N-terminal region and the C-terminal region.

The N-terminal region of PDE3B contains a unique feature that is not found in other PDEs. It has a long N-terminal region that contains a conserved region known as the N-terminal hypervariable region (N-VIP). This region is involved in the formation of a disulfide bond, which is a common structural feature in proteins that involves the formation of a covalent bond between two amino acids. The N-VIP region is also involved in the regulation of protein stability and in the formation of protein- protein interactions.

The C-terminal region of PDE3B contains a conserved region known as the C-terminal hypervariable region (C-VIP). This region is involved in the regulation of protein stability and in the formation of protein-protein interactions. is also involved in the regulation of protein dynamics and in the modulation of protein-protein interactions.

PDE3B is involved in the regulation of many cellular processes, including cell signaling, cell division, and cell growth. It is a key enzyme in the hydrophobic-hydrophilic balance process, which is essential for cell signaling. During this process, PDE3B helps to regulate the formation of disulfide bonds, which are important for the stability and function of many proteins.

In addition to its role in cell signaling, PDE3B is also a potential drug target. The N-terminal VIP region of PDE3B has been shown to be involved in the regulation of protein stability and in the formation of protein-protein interactions. This suggests that Targeting this region may be a useful way to treat diseases that are caused by the misregulation of protein stability or protein-protein interactions.

The C-terminal VIP region of PDE3B has also been shown to be involved in the regulation of protein dynamics and in the modulation of protein-protein interactions. This suggests that targeting this region may also be a useful way to treat diseases that are caused by the misregulation of protein dynamics or protein-protein interactions.

Conclusion

PDE3B is a key enzyme that is involved in the hydrophobic-hydrophilic balance process, which is essential for cell signaling. It is a protein that has a unique structure, as it consists of a catalytic domain that is divided into two distinct regions: the N-terminal region and the C-terminal region. The N-terminal VIP region of PDE3B has been shown to be involved in the regulation of protein stability and in the formation of protein-protein interactions, while the C-terminal VIP region has been shown to be involved in the regulation of protein dynamics and in the modulation of protein-protein interactions.

With its unique structure and its involvement in the regulation of cell signaling, PDE3B makes it an attractive drug target or biomarker. The N-terminal VIP region has been shown to be involved in the regulation of protein stability and in the formation of protein-protein interactions, while the C-terminal VIP region has been shown to be involved in the regulation of protein dynamics and in the modulation of protein-protein interactions. These properties make PDE3B a promising target for the development of new drugs for a variety of diseases.

Protein Name: Phosphodiesterase 3B

Functions: Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process (PubMed:14592490, PubMed:21393242). Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling (PubMed:21393242). Controls cardiac contractility by reducing cAMP concentration in cardiocytes (By similarity)

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