Target Name: PEAK1
NCBI ID: G79834
Other Name(s): Sugen kinase 269 | Pseudopodium enriched atypical kinase | SGK269 | tyrosine-protein kinase SgK269 | PEAK1 variant 2 | pseudopodium enriched atypical kinase 1 | Inactive tyrosine-protein kinase PEAK1 | sugen kinase 269 | Pseudopodium enriched atypical kinase 1, transcript variant 2 | KIAA2002 | NKF3 kinase family member | Pseudopodium-enriched atypical kinase 1 | Inactive tyrosine-protein kinase PEAK1 (isoform a) | FLJ21140 | Tyrosine-protein kinase SgK269 | FLJ34483 | PEAK1_HUMAN

PEAK1: A Protein Regulator of Insulin Secretion and Cellular Processes

PEAK1 (Sugen kinase 269) is a protein that is expressed in a variety of tissues, including the brain, pancreas, and muscle. It is a key regulator of cell growth and metabolism, and is involved in the development and maintenance of tissues.

One of the unique features of PEAK1 is its role in the regulation of insulin secretion from the pancreas. Insulin is a hormone that plays a critical role in regulating blood sugar levels, and it is produced by the pancreas. PEAK1 is involved in the regulation of the amount of insulin that is released by the pancreas, and is thought to play a key role in the development of insulin resistance.

In addition to its role in insulin regulation, PEAK1 is also involved in the regulation of a variety of other cellular processes. For example, it is involved in the regulation of cell death, cell signaling, and protein synthesis.

Given its involvement in so many cellular processes, PEAK1 is a promising target for drug development. Researchers are currently working to develop small molecules that can inhibit the activity of PEAK1, with the goal of using these drugs to treat a variety of diseases.

One of the challenges in the development of PEAK1-based drugs is the difficulty of predicting the exact mechanism of action of these drugs. While PEAK1 is involved in many different cellular processes, it is not clear how it is responsible for the effects of many drugs. This makes it difficult to design small molecules that specifically target PEAK1.

However, researchers are making progress in understanding the mechanisms of PEAK1 and are working to develop new approaches to the treatment of diseases that are influenced by its activity. For example, studies have shown that PEAK1 is involved in the regulation of muscle growth and that it is a key regulator of muscle protein synthesis. This suggests that drugs that can inhibit the activity of PEAK1 may be effective in treating muscle-related diseases.

In addition to its potential as a drug target, PEAK1 is also being studied as a potential biomarker. The regulation of insulin secretion by PEAK1 is a key factor in the development of insulin resistance, a condition that is associated with a variety of diseases, including type 2 diabetes. Therefore, measuring the activity of PEAK1 may be a useful diagnostic tool for these diseases.

Overall, PEAK1 is a protein that is involved in a variety of cellular processes and is a potential target for drug development. While the development of PEAK1-based drugs is still in its early stages, the potential for these drugs to treat a variety of diseases makes them an important area of research.

Protein Name: Pseudopodium Enriched Atypical Kinase 1

Functions: Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:23105102, PubMed:20534451, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654)

More Common Targets

PEAK3 | PEAR1 | PeBoW complex | PEBP1 | PEBP1P2 | PEBP4 | PECAM1 | PECR | PEDS1 | PEDS1-UBE2V1 | PEF1 | PEG10 | PEG13 | PEG3 | PEG3-AS1 | PELATON | PELI1 | PELI2 | PELI3 | PELO | PELP1 | PELP1-DT | PEMT | PENK | PENK-AS1 | PEPD | Peptidyl arginine deiminase (PAD) | Peptidylprolyl Isomerase | PER1 | PER2 | PER3 | PER3P1 | PERM1 | Peroxiredoxin | Peroxisome Proliferator-Activated Receptors (PPAR) | PERP | PES1 | PET100 | PET117 | PEX1 | PEX10 | PEX11A | PEX11B | PEX11G | PEX12 | PEX13 | PEX14 | PEX16 | PEX19 | PEX2 | PEX26 | PEX3 | PEX5 | PEX5L | PEX5L-AS2 | PEX6 | PEX7 | PF4 | PF4V1 | PFAS | PFDN1 | PFDN2 | PFDN4 | PFDN5 | PFDN6 | PFKFB1 | PFKFB2 | PFKFB3 | PFKFB4 | PFKL | PFKM | PFKP | PFN1 | PFN1P2 | PFN1P3 | PFN1P4 | PFN1P6 | PFN1P8 | PFN2 | PFN3 | PFN4 | PGA3 | PGA4 | PGA5 | PGAM1 | PGAM1P5 | PGAM1P7 | PGAM1P8 | PGAM2 | PGAM4 | PGAM5 | PGAM5-KEAP1-NRF2 Complex | PGAP1 | PGAP2 | PGAP3 | PGAP4 | PGAP6 | PGBD1 | PGBD2 | PGBD3