PEX13: A Promising Drug Target and Biomarker for Peroxisomal Membrane Protein

Target Name: PEX13

NCBI ID: G5194

PEX13: A Promising Drug Target and Biomarker for Peroxisomal Membrane Protein

Abstract: Peroxisomal membrane protein PEX13 has been identified as a potential drug target and biomarker for various diseases, including neurodegenerative disorders, cancer, and autoimmune diseases. This article summarizes the current understanding of PEX13, its functions, and potential therapeutic applications, as well as the progress of research in this field.

Introduction: Peroxisomes are organelles that are involved in the processing and storage of various molecules, including toxins and diseases. Peroxisomal membrane protein PEX13 is a key component of peroxisomes and plays a crucial role in their function. PEX13 is composed of a transmembrane protein that contains multiple domains, including an extracellular domain, a transmembrane domain, and an intracellular domain. The intracellular domain of PEX13 is responsible for the formation of the peroxisomal membrane, which is a distinct membrane system that functions as an organelle that encapsulates various cellular organelles.

PEX13 functions: PEX13 is involved in various cellular processes, including the regulation of intracellular signaling pathways, cellular signaling, and intracellular transport. PEX13 has been shown to play a critical role in the regulation of mitochondrial function and to modulate the levels of intracellular signaling pathways, including TGF-β, NF-kappa-B, and PI3K. PEX13 has also been shown to be involved in the regulation of cellular apoptosis, which is a critical mechanism for the elimination of damaged or dysfunctional cells.

Drug targeting: PEX13 has been identified as a potential drug target for various diseases due to its unique functions and the potential impact it can have on cellular processes. One of the main drug targets for PEX13 is neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. These disorders are characterized by the progressive loss of brain cells and can result in significant cognitive and behavioral impairments. PEX13 has been shown to play a crucial role in the regulation of neurodegenerative disorders by modulating the levels of intracellular signaling pathways, including TGF-β, NF-kappa-B, and PI3K.

Another potential drug target for PEX13 is cancer. PEX13 has been shown to be involved in the regulation of cellular apoptosis, which is a critical mechanism for the elimination of damaged or dysfunctional cells. Therefore, PEX13 has the potential to be a useful biomarker for cancer and to identify potential therapeutic approaches for cancer treatment.

Biomarker potential: PEX13 has also been identified as a potential biomarker for various diseases, including neurodegenerative disorders, cancer, and autoimmune diseases. The detection and quantification of PEX13 levels in various biological samples, such as brain, plasma, and urine, can be used as a diagnostic tool for these diseases. Additionally, the regulation of PEX13 levels can be used as a therapeutic target by modulating the levels of PEX13 in various cellular processes, including intracellular signaling pathways.

Conclusion: In conclusion, PEX13 is a peroxisomal membrane protein that plays a crucial role in various cellular processes, including the regulation of intracellular signaling pathways and cellular apoptosis. Its functions make it an attractive drug target for neurodegenerative disorders, cancer, and autoimmune diseases. Further research is needed to fully understand the role of PEX13 in these diseases and to develop effective therapies that target PEX13.

Protein Name: Peroxisomal Biogenesis Factor 13

Functions: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:9653144, PubMed:8858165, PubMed:28765278). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:9653144, PubMed:8858165, PubMed:28765278). Involved in the import of PTS1- and PTS2-type containing proteins (PubMed:9653144, PubMed:8858165)

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