PEX2: A promising drug target and biomarker for peroxisome biogenesis

Target Name: PEX2

NCBI ID: G5828

PEX2: A promising drug target and biomarker for peroxisome biogenesis

Peroxisomes are organelles that are involved in the detoxification process in various cell types. They are characterized by the presence of a special type of protein called peroxisome-associated protein (PAP), which is responsible for the formation and function of peroxisomes. Peroxisomes are also known as organelles of interest (ROMs) due to their unique structure and function.

One of the key proteins involved in peroxisome formation and function is PEX2. Peroxisome biogenesis factor 2 (PEX2) is a protein that plays a crucial role in the regulation of peroxisome biogenesis. It is a 24-kDa protein that is expressed in various cell types, including epithelial, hepatic, and neural cells.

PEX2 functions as a negative regulator of peroxisome biogenesis by inhibiting the activity of the transcription factor, nuclear factor kappa B (NF-kappa-B). NF-kappa-B is a well-known protein that plays a role in various cellular processes, including inflammation, cell survival, and metabolism.

In conclusion, PEX2 is a protein that has great potential as a drug target or biomarker. Its unique function in peroxisome formation and regulation makes it an attractive target for future research and development.

Structure and Function

PEX2 is a member of the PEX gene family, which is characterized by the presence of a characteristic C-type trypsin-like domain and a distinct N-terminus. PEX2 is a 24-kDa protein that has a unique molecular structure, including a 140 amino acid long N-terminus, a 21 amino acid long transmembrane region, and a 64 amino acid long C-terminus.

PEX2 plays a crucial role in peroxisome formation and regulation. It is a negative regulator of peroxisome biogenesis by inhibiting the activity of the transcription factor, nuclear factor kappa B (NF-kappa-B). NF-kappa-B is a well-known protein that plays a role in various cellular processes, including inflammation, cell survival, and metabolism.

PEX2 functions as a negative regulator of peroxisome biogenesis by inhibiting the activity of the transcription factor, nuclear factor kappa B (NF-kappa-B). NF-kappa-B is a well-known protein that plays a role in various cellular processes, including inflammation, cell survival, and metabolism.

Expression and Localization

PEX2 is expressed in various cell types, including epithelial, hepatic, and neural cells. It is mainly localized to the peroxisome, where it functions as a negative regulator of peroxisome biogenesis.

PEX2 is a negative regulator of peroxisome biogenesis by inhibiting the activity of the transcription factor, nuclear factor kappa B (NF-kappa-B). NF-kappa-B is a well-known protein that plays a role in various cellular processes, including inflammation, cell survival, and metabolism.

Drug Targeting

PEX2 is a drug target of great potential due to its unique function in peroxisome regulation. Its function as a negative regulator of peroxisome biogenesis makes it an attractive target for small molecules that can inhibit its activity.

In addition, its unique molecular structure and localization to the peroxisome make it an attractive target for small molecules that can inhibit its activity.

Biomarker

PEX2 can also be used as a biomarker for peroxisome dysfunction. Its function as a negative regulator of peroxisome biogenesis makes it an attractive target for small molecules that can inhibit its activity.

Conclusion

PEX2 is a protein that has great potential as

Protein Name: Peroxisomal Biogenesis Factor 2

Functions: E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:24662292). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase (By similarity). PEX2 ubiquitinates PEX5 during its passage through the retrotranslocation channel: catalyzes monoubiquitination of PEX5 at 'Cys-11', a modification that acts as a signal for PEX5 extraction into the cytosol (By similarity). Required for pexophagy in response to starvation by mediating ubiquitination of peroxisomal proteins, such as PEX5 and ABCD3/PMP70 (PubMed:27597759). Also involved in the response to reactive oxygen species (ROS) by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of PNPLA2/ATGL, thereby regulating lipolysis (PubMed:34903883)

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