PEX11B: A Transmembrane Protein Involved in Cell Signaling and Cell Adhesion

Target Name: PEX11B

NCBI ID: G8799

PEX11B: A Transmembrane Protein Involved in Cell Signaling and Cell Adhesion

PEX11B (PEX11beta), also known as PEX11beta, is a protein that is expressed in various tissues of the body, including the brain, heart, lungs, and gastrointestinal tract. It is a member of the PEX family of transmembrane proteins, which are involved in a variety of cellular processes, including signaling, ion transport, and regulation of cell adhesion. PEX11B is unique due to its unique structure and function.

PEX11B is a 11-kDa protein that is expressed in the brain and other tissues of the body. It is highly conserved, with a calculated amino acid sequence of 1,184 amino acids. PEX11B is characterized by a N-terminal transmembrane domain, a unique feature for a protein of its size. This domain is involved in the formation of the protein's transmembrane structure and may be involved in its functions.

PEX11B is involved in a variety of cellular processes, including the regulation of ion and solute transport, cell signaling, and cell adhesion. One of its most well-known functions is its role in the regulation of sodium channels, which are responsible for the flow of electrical current through cells.

PEX11B is also involved in the regulation of the expression of other genes. Studies have shown that PEX11B can interact with the protein Trpm2, which is involved in the regulation of pain perception. This interaction may be involved in the regulation of pain sensitivity.

PEX11B is also involved in the regulation of cell adhesion. Its unique structure and function may be involved in the formation of tight junctions, which are responsible for the separation of cells in tissues.

The discovery and characterization of PEX11B

The discovery and characterization of PEX11B was made through a combination of biochemical, genetic, and functional studies. The protein was first identified through a screening experiment for potential drug targets using the PES database, a database of protein expression and function.

The first biochemical study of PEX11B was conducted using the PEX11B cell line, which was created by the expression of PEX11B cDNA in a cell line that was susceptible to the neurotransmitter glutamate. The study showed that PEX11B was able to translocate to the cell membrane and was involved in the regulation of glutamate uptake and release.

The next step in the characterization of PEX11B was a genetic study to determine its gene expression and localization. The PEX11B gene was cloned into a plasmid and introduced into the SV40 cell line. The resulting cells were then grown and the expression of PEX11B was detected using a variety of techniques, including immunofluorescence and Western blotting. The results showed that PEX11B was expressed in the SV40 cell line and was localized to the endoplasmic reticulum (ER) and the cytoplasm.

Finally, the function of PEX11B was determined through a series of functional studies. The first experiment was a cell-based assay to determine the effects of PEX11B on the movement of neurotransmitters, such as glutamate. The results showed that PEX11B was able to inhibit the movement of glutamate into the cell, which is consistent with its function as a regulator of neurotransmitter uptake and release.

Another study showed the effects of PEX11B on the formation of tight junctions, which are responsible for the separation of cells in tissues. The results showed that PEX11B was able to

Protein Name: Peroxisomal Biogenesis Factor 11 Beta

Functions: Involved in peroxisomal proliferation (PubMed:9792670). May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane (PubMed:12618434). Promotes membrane protrusion and elongation on the peroxisomal surface (PubMed:20826455)

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