Regulation of Protein Quality and Stability (G27043)

Target Name: PELP1

NCBI ID: G27043

Regulation of Protein Quality and Stability

PELP1 (Proteasome-light dependent protein 1) is a protein that is expressed in various tissues throughout the body. It is a key regulator of the proteasome, a complex protein that helps to break down and process large proteins into smaller peptides. PELP1 has been shown to play a crucial role in the regulation of protein quality and has been identified as a potential drug target.

The Proteasome

The proteasome is a complex protein that is responsible for breaking down and processing large proteins into smaller peptides. It is composed of a protein complex called the 26S subunit and a protein complex called the 19S subunit. The 26S subunit is the largest subunit of the proteasome and is responsible for breaking down the largest proteins. The 19S subunit is the smallest subunit of the proteasome and is responsible for processing the peptides that are generated by the 26S subunit.

PELP1 as a Drug Target

PELP1 has been shown to play a crucial role in the regulation of protein quality. It is a key regulator of the proteasome and has been shown to play a role in the regulation of protein stability, localization, and degradation.

One of the key functions of PELP1 is its role in the regulation of the proteasome. PELP1 helps to ensure that the proteasome has access to the necessary tools to properly break down and process proteins. It does this by regulating the composition of the proteasome complex and by participating in the regulation of the stability and localization of the proteasome.

In addition to its role in the regulation of the proteasome, PELP1 has also been shown to play a role in the regulation of protein stability and localization. PELP1 helps to ensure that proteins are properly stability and localized in their cells so that they can perform their necessary functions.

PELP1 as a Biomarker

PELP1 has also been identified as a potential biomarker for a variety of diseases. For example, PELP1 has been shown to be elevated in the blood of individuals with certain types of cancer, such as lung cancer and colon cancer. This suggests that PELP1 may be a useful biomarker for the diagnosis and treatment of these diseases.

In addition to its potential as a biomarker, PELP1 has also been shown to be involved in the regulation of cellular processes that are important for the growth, development, and survival of cells. For example, PELP1 has been shown to play a role in the regulation of cell division and the cell cycle.

Conclusion

PELP1 is a protein that has been shown to play a crucial role in the regulation of protein quality and stability. It is a potential drug target and has been identified as a potential biomarker for a variety of diseases. Further research is needed to fully understand the role of PELP1 in the regulation of protein quality and to develop effective treatments for the prevention and treatment of diseases that are dependent on its regulation.

Protein Name: Proline, Glutamate And Leucine Rich Protein 1

Functions: Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors (PubMed:14963108). Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:21326211). May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K

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