PECAM1: A Potential Drug Target and Biomarker (G5175)

Target Name: PECAM1

NCBI ID: G5175

PECAM1: A Potential Drug Target and Biomarker

PECAM1 (Peri-Conjugate Epithelial cell adhesion molecule 1) is a protein that is expressed in the peri-conjugate epithelial cell (CEC) lineages, which are found in various body tissues and organs. CECs are responsible for forming the lining of various body surfaces and organs, including the skin, gut, and respiratory tract. PECAM1 is a transmembrane protein that is involved in cell adhesion, migration, and signaling.

PECAM1 is a potential drug target and has been identified as a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. In this article, we will discuss the biology of PECAM1, its potential drug target status, and its potential as a biomarker.

Biology of PECAM1

PECAM1 is a transmembrane protein that is composed of four extracellular domains and a transmembrane region. It consists of a single copy of the extracellular domain that is involved in cell adhesion and migration. The extracellular domain of PECAM1 consists of a cytoplasmic domain that is involved in cell adhesion and a transmembrane region that is involved in the regulation of cell signaling pathways.

PECAM1 is involved in several cell signaling pathways, including the TGF-β pathway and the Wnt pathway. The TGF-β pathway is a well-established pathway that is involved in cell growth, differentiation, and survival, and PECAM1 is involved in the regulation of TGF-β signaling in CECs.

In addition to its involvement in TGF-β signaling, PECAM1 is also involved in the regulation of cell adhesion. PECAM1 is a member of the cadherin family, which is a family of transmembrane proteins that are involved in cell adhesion.

PECAM1 is also involved in the regulation of cell migration. PECAM1 has been shown to be involved in the regulation of cell migration in CECs, and it has been shown to play a role in the development of cancer.

PECAM1 has also been shown to be involved in the regulation of cell signaling pathways that are involved in cell survival and proliferation. PECAM1 has been shown to be involved in the regulation of the PI3K/Akt signaling pathway, which is involved in the regulation of cell survival and proliferation.

PECAM1 as a drug target

PECAM1 is a potential drug target due to its involvement in several cell signaling pathways that are involved in the development and progression of various diseases.

PECAM1 has been shown to be involved in the regulation of TGF-β signaling, which is involved in the development and progression of cancer. In addition, PECAM1 is also involved in the regulation of cell adhesion, which is involved in the development and progression of neurodegenerative diseases.

PECAM1 has also been shown to be involved in the regulation of cell migration, which is involved in the development and progression of various diseases, including cancer.

In addition to its involvement in these signaling pathways, PECAM1 is also involved in the regulation of cell signaling pathways that are involved in cell survival and proliferation.

PECAM1 as a biomarker

PECAM1 has been shown to be involved in the regulation of several diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. This suggests that PECAM1 may be a useful biomarker for these diseases.

In addition to its potential as a drug target, PECAM1 has also been shown to be involved in the regulation of cell signaling pathways that are involved in the development and progression of various diseases. This suggests that PECAM1 may be a useful biomarker for

Protein Name: Platelet And Endothelial Cell Adhesion Molecule 1

Functions: Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis (By similarity)

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