PDZD8: A Potential Drug Target and Biomarker (G118987)

Target Name: PDZD8

NCBI ID: G118987

PDZD8: A Potential Drug Target and Biomarker

PDZD8 is a protein that is expressed in the brain and is known for its role in the development and progression of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. The protein is a key player in the huntingtin gene family, which is known for its role in the development of neurodegenerative diseases.

PDZD8 has been shown to interact with several other proteins, including huntingtin-1, -2, -3, and -4. It is also known to play a role in the regulation of the expression of huntingtin genes. This suggests that PDZD8 may be a drug target that can be targeted with small molecules or other therapeutic agents.

In addition to its role in the huntingtin gene family, PDZD8 has also been shown to play a role in the regulation of synaptic plasticity, which is the ability of the brain to change and adapt over time. This suggests that PDZD8 may be a valuable biomarker for the diagnosis and treatment of neurodegenerative diseases.

PDZD8 is also a good candidate for a biomarker diagnostic test for neurodegenerative diseases. This is because it is highly expressed in the brain and is not expressed in other tissues, which makes it a reliable and sensitive marker for the diagnosis of neurodegenerative diseases.

PDZD8 has also been shown to be involved in the regulation of inflammation, which is a hallmark feature of neurodegenerative diseases. This suggests that PDZD8 may be a potential target for therapeutic agents that are designed to reduce inflammation in neurodegenerative diseases.

In conclusion, PDZD8 is a protein that has the potential to be a drug target or biomarker for neurodegenerative diseases. Further research is needed to determine the exact role of PDZD8 in these diseases and to develop effective therapeutic agents that can target it.

Protein Name: PDZ Domain Containing 8

Functions: Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes (PubMed:29097544). PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer (PubMed:29097544). In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons (PubMed:29097544). Plays an indirect role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). May inhibit herpes simplex virus 1 infection at an early stage (PubMed:21549406)

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