PEA15: A Potential Drug Target and Biomarker for Proliferation and Apoptosis

Target Name: PEA15

NCBI ID: G8682

PEA15: A Potential Drug Target and Biomarker for Proliferation and Apoptosis

Introduction

Proliferation and apoptosis are essential processes in cell biology, and they play a crucial role in maintaining tissue homeostasis and regulating growth and development. Disruptions in these processes can lead to various diseases, including cancer, neurodegenerative disorders, and developmental delays. The Proliferation and Apoptosis Adaptor (PA) protein 15 (PEA15) is a key regulator that promotes the growth and survival of cancer cells. In this article, we will explore the biology of PEA15 and its potential as a drug target and biomarker.

PEA15: Structure and Function

PEA15 is a 21-kDa protein that is expressed in various tissues, including muscle, liver, and brain. It is a member of the PA family, which includes several related proteins that play a crucial role in cell proliferation and apoptosis. The PA family proteins are involved in the regulation of cell growth, survival, and angiogenesis. PEA15 is characterized by a unique N-terminal domain that contains a nucleotide-binding oligomerization domain (NBO), a conserved nucleotide-binding motif (NBM), and a C -terminal domain that contains a protein-disulfide-bonded fragment (PDB) and a leucine-rich repeat (LRR) domain.

PEA15 functions as a negative regulator of cell proliferation. It inhibits the G1 checkpoint, which is a critical regulatory mechanism that ensures that cells divide in a controlled manner. The G1 checkpoint is a complex series of proteins that regulate the growth and cycle of cells. PEA15 functions by binding to the G1-specific kinase, which is a critical enzyme for the G1 checkpoint. By binding to the kinase, PEA15 inhibits the phosphorylation of the target protein, which results in the inhibition of cell proliferation.

PEA15 also functions as an antioxidant.Free radical(1)

PEA15 is involved in the detoxification of superoxide and other reactive oxygen species (ROS) that can damage cellular components and contribute to the development of oxidative stress-induced diseases. PEA15 has been shown to have antioxidant properties by donating electrons to ROS, reducing their oxidation and potential damage to cells.

PEA15 is also involved in the regulation of cell apoptosis. Apoptosis is a natural process that eliminates damaged or dysfunctional cells to prevent the development of cancer. PEA15 is a critical regulator of cell apoptosis by promoting the expression of apoptosis-related genes (apoptosis-related genes gene) and activating the caspase-3-dependent pathway of apoptosis.

PEA15 Interactions

PEA15 interacts with various protein partners, including the transcription factor, NF-kappa-B, and the protein kinase kinase (PKC). These interactions are important for the regulation of cell proliferation and apoptosis.

PEA15 can interact with the transcription factor, NF-kappa-B. The NBM of PEA15 is involved in the interaction with the NF-kappa-B protein, which is a critical transcription factor that regulates various cellular processes, including cell proliferation and apoptosis.

PEA15 can interact with the protein kinase, PKC. The PDB of PEA15 is involved in the interaction with the PKC protein, which is a critical enzyme that regulates the growth and cycle of cells.

Mutations in PEA15

Mutations in PEA15 have been observed that affect its function. Several studies have shown that PEA15 mutants have altered cellular behavior, including increased cell proliferation and enhanced resistance to apoptosis.

Conclusion

PEA15 is a protein that plays a crucial role in the regulation of cell proliferation and apoptosis. Its function is regulated by various interactions with other proteins, including transcription factors and protein kinases. Mutations in PEA15 have been observed that affect its function, and its potential as a drug target or biomarker is under investigation. Further studies are needed to fully understand the biology of PEA15 and its potential as a drug target or biomarker.

Protein Name: Proliferation And Apoptosis Adaptor Protein 15

Functions: Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface

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