PDXDC1: A Protein Implicated in Neural Connections and Disease

Target Name: PDXDC1

NCBI ID: G23042

Other Name(s): PDXDC1 variant 4 | Pyridoxal-dependent decarboxylase domain-containing protein 1 (isoform 4) | LP8165 | PDXDC1 variant 1 | Pyridoxal-dependent decarboxylase domain-containing protein 1 (isoform 6) | Pyridoxal dependent decarboxylase domain containing 1, transcript variant 9 | Pyridoxal dependent decarboxylase domain containing 1, transcript variant 10 | Pyridoxal-dependent decarboxylase domain-containing protein 1 isoform 10 | Pyridoxal dependent decarboxylase domain containing 1, transcript variant 4 | Pyridoxal-dependent decarboxylase domain-containing protein 1 isoform 9 | PDXDC1 variant 10 | Pyridoxal-dependent decarboxylase domain-containing protein 1 (isoform 1) | Pyridoxal-dependent decarboxylase domain-containing protein 1, transcript variant 6 | PDXD1_HUMAN | pyridoxal dependent decarboxylase domain containing 1 | Pyridoxal dependent decarboxylase domain containing 1, transcript variant 1 | Pyridoxal-dependent decarboxylase domain-containing protein 1 | pyridoxal-dependent decarboxylase domain-containing protein 1-like | PDXDC1 variant 9 | PDXDC1 variant 6 | KIAA0251

PDXDC1: A Protein Implicated in Neural Connections and Disease

PDXDC1 (Peripheral Delimiting Dendrites) is a protein that is expressed in the brain and is involved in the development and maintenance of neural connections. It is a key player in the regulation of synaptic plasticity, which is the ability of the brain to change and adapt over time.

Research has shown that PDXDC1 plays a crucial role in the formation and maintenance of synaptic plasticity, particularly in the development of memories and learning. It is also involved in the regulation of pain and anxiety, and has been linked to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and depression.

One of the key challenges in studying PDXDC1 is its complex structure and the difficulty of studying a protein that is expressed in such a large and diverse system. Researchers have used a variety of techniques to study its behavior, including biochemical, cellular, and animal models.

One of the most promising approaches to studying PDXDC1 is to use small molecules to identify potential drug targets. This is an approach that involves using drugs that are designed to interact with specific proteins to understand how they work and how they can be used to treat disease.

One of the most promising small molecules that has been identified as a potential drug target for PDXDC1 is called PDXDC1-targeting peptide 1 (PDXDC1-T1). This peptide is designed to bind to a specific epitope (a protein location) on PDXDC1 and has been shown to reduce the expression of PDXDC1 in brain cells.

In addition to its potential as a drug target, PDXDC1 is also a potential biomarker for various neurological disorders. For example, it has been shown to be reduced in the brains of individuals with Alzheimer's disease, and may be a useful diagnostic marker for this disease.

In conclusion, PDXDC1 is a protein that is involved in the development and maintenance of synaptic plasticity, and has been linked to a variety of neurological disorders. The study of its behavior using small molecules and its potential as a drug target and biomarker make it an attractive target for future research.

Protein Name: Pyridoxal Dependent Decarboxylase Domain Containing 1

More Common Targets