PDLIM5: Regulator of Protein Degradation and Homeostasis (G10611)

Target Name: PDLIM5

NCBI ID: G10611

PDLIM5: Regulator of Protein Degradation and Homeostasis

PDLIM5 (Proteasome-Driven Limited Acid-Inducible Module 5) is a protein that is expressed in various tissues and cells throughout the body. It is a key regulator of the proteasome, which is a complex protein that helps to break down and remove proteins that are no longer needed. PDLIM5 is involved in the regulation of protein degradation and has been implicated in a number of cellular processes, including cell growth, differentiation, and response to stimuli.

One of the key functions of PDLIM5 is its role in the regulation of protein homeostasis, which is the ability of cells to maintain the correct balance of protein synthesis and degradation. This is important for maintaining the stability of cellular processes and for ensuring the integrity of the cell.

PDLIM5 is also involved in the regulation of cell adhesion and migration. It is a key regulator of the cadherin protein, which is important for the formation of tight junctions and for the development of tissues that are organized in a specific pattern. PDLIM5 has also been shown to play a role in the regulation of cell migration, which is important for the development of tissues and organs and for the maintenance of tissue homeostasis.

PDLIM5 is also involved in the regulation of cell survival and apoptosis. It is a key regulator of the p53 protein, which is important for the regulation of DNA damage and cell apoptosis. PDLIM5 has been shown to play a role in the regulation of p53 function and has been implicated in the development of a number of diseases, including cancer.

PDLIM5 is also involved in the regulation of protein synthesis and degradation in the endoplasmic reticulum (ER). The ER is a complex organelle that is responsible for the synthesis and modification of proteins, and PDLIM5 is involved in the regulation of the ER-associated degradation pathway, which is the process by which proteins that are no longer needed are removed from the ER and degraded.

PDLIM5 is also involved in the regulation of protein synthesis and degradation in the cytosol. by which proteins that are no longer needed are removed from the cytosol and degraded.

In conclusion, PDLIM5 is a protein that is involved in a number of cellular processes and has been implicated in a number of diseases. Further research is needed to fully understand its functions and to develop new treatments for these diseases.

Protein Name: PDZ And LIM Domain 5

Functions: May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation

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