ITLN1: A Potential Drug Target and Biomarker (G55600)

Target Name: ITLN1

NCBI ID: G55600

ITLN1: A Potential Drug Target and Biomarker

ITLN1 (Galactofuranose-binding lectin) is a protein that is expressed in various tissues of the body, including the liver, spleen, and blood cells. It is a type oflectin, which is a protein that is found in the extracellular matrix (ECM) and interacts with extracellular matrix components, such as collagen and hyaluronic acid. ITLN1 is also known as CD63, and it is a member of the Integrin family.

ITLN1 has been shown to play a role in many different processes in the body, including inflammation, fibrosis, and cancer. It is also a potential drug target and biomarker. In this article, we will discuss the biology and functions of ITLN1, and its potential as a drug target.

Biogenesis and localization

ITLN1 is a heparan sulfate proteoglycan that is expressed in various tissues of the body, including the liver, spleen, and blood cells. It is synthesized in the liver and then secreted into the bloodstream. ITLN1 is mainly expressed in the liver, with lower levels found in the spleen and blood cells. The liver is the primary site of ITLN1 synthesis, and it is also the site of its localization.

ITLN1 is localized to the endoplasmic reticulum (ER), which is the system for the transport and storage of proteins in the cell. In the ER, ITLN1 is involved in the degradation of extracellular matrix (ECM) components, such as collagen and hyaluronic acid. It is also involved in the regulation of cell signaling pathways, including the TGF-β pathway.

Function and interactions

ITLN1 has been shown to play a role in many different processes in the body, including inflammation, fibrosis, and cancer. It is involved in the regulation of cellular signaling pathways, including the TGF-β pathway. This pathway is involved in the regulation of cell growth, differentiation, and survival, and is a key factor in the development and progression of many diseases, including cancer.

ITLN1 is also involved in the regulation of inflammation. It has been shown to play a role in the regulation of immune responses, including the regulation of T cell activity. ITLN1 has also been shown to play a role in the regulation of inflammation in the liver, where it is involved in the regulation of the bile salt export system.

In addition to its role in inflammation and fibrosis, ITLN1 is also involved in the regulation of cell signaling pathways that are involved in cancer development. It is involved in the regulation of the PI3K/Akt signaling pathway, which is involved in the regulation of cell growth, survival, and angiogenesis.

ITLN1 is also a potential drug target and biomarker. Its unique structure and localization to the ER make it an attractive target for small molecules and other therapeutic agents. In addition, its involvement in cellular signaling pathways makes it a potential biomarker for a variety of diseases, including cancer.

Conclusion

ITLN1 is a protein that is expressed in various tissues of the body and plays a role in the regulation of many different cellular processes in the body. Its localization to the ER and its involvement in cellular signaling pathways make it an attractive target for small molecules and other therapeutic agents. In addition, its potential as a drug target and biomarker make ITLN1 a promising target for the development of new treatments for a variety of diseases. Further research is needed to fully understand the biology and functions of ITLN1 and its potential as a drug

Protein Name: Intelectin 1

Functions: Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed:11313366, PubMed:26148048). Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (PubMed:26148048). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris (PubMed:26148048). Does not bind human glycans (PubMed:26148048). Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes (PubMed:16531507). Increases AKT phosphorylation in the absence and presence of insulin (PubMed:16531507). May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (PubMed:11747454, PubMed:23921499)

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