NSUN3: A Potential Drug Target and Biomarker in the Sun Domain Family

Target Name: NSUN3

NCBI ID: G63899

NSUN3: A Potential Drug Target and Biomarker in the Sun Domain Family

The Sun domain family, member 3 (NSUN3) is a protein that plays a crucial role in the regulation of cell growth, differentiation, and survival.NSUN3 is a 25kDa protein that is expressed in various tissues and cell types, including neural, muscle, and epithelial cells. It is involved in the development and maintenance of tissues and organs, as well as in the regulation of cell signaling pathways.

NSUN3 has been identified as a potential drug target and biomarker due to its unique structure and function. It has been shown to play a role in various diseases, including neurodegenerative disorders, cancer, and inflammation.

Potential Drug Target

One of the most promising aspects of NSUN3 is its potential as a drug target.NSUN3 has been shown to interact with various signaling pathways, including the TGF-β pathway. This suggests that NSUN3 may be a good candidate for drugs that target the TGF-β pathway.

TGF-β is a well-known signaling pathway that plays a role in the development and maintenance of tissues and organs, as well as in the regulation of cell signaling pathways. It is involved in the regulation of cell proliferation, differentiation, and survival.

Studies have shown that NSUN3 can interact with various TGF-β signaling pathway components, including the transcription factor Smad. This suggests that NSUN3 may be a good candidate for drugs that target the TGF-β pathway.

Biomarker

In addition to its potential as a drug target, NSUN3 has also been identified as a potential biomarker for various diseases.

One of the most promising aspects of NSUN3 as a biomarker is its expression in various tissues and cell types. This suggests that NSUN3 may be a good candidate for use as a biomarker for diseases that affect these tissues and cell types.

Studies have shown that NSUN3 is expressed in various tissues and cell types, including neural, muscle, and epithelial cells. This suggests that NSUN3 may be a good candidate for use as a biomarker for diseases that affect these tissues and cell types.

Conclusion

In conclusion, NSUN3 is a protein that has the potential to be a drug target and biomarker. Its unique structure and function make it an attractive candidate for both drug development and biomarker research.

NSUN3 has been shown to play a role in the regulation of cell growth, differentiation, and survival, as well as in the development and maintenance of tissues and organs. Its interaction with the TGF-β pathway suggests that it may be a good candidate for drugs that target this pathway.

In addition, NSUN3 has also been identified as a potential biomarker for various diseases. Its expression in various tissues and cell types makes it a promising candidate for use as a biomarker for these diseases.

Overall, NSUN3 is a protein that has the potential to be a valuable drug target and biomarker. Further research is needed to fully understand its function and potential in these areas.

Protein Name: NOP2/Sun RNA Methyltransferase 3

Functions: Mitochondrial tRNA methyltransferase that mediates methylation of cytosine to 5-methylcytosine (m5C) at position 34 of mt-tRNA(Met) (PubMed:27497299, PubMed:27214402, PubMed:27356879). mt-tRNA(Met) methylation at cytosine(34) takes place at the wobble position of the anticodon and initiates the formation of 5-formylcytosine (f(5)c) at this position (PubMed:27497299, PubMed:27214402, PubMed:27356879). mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon, expanding codon recognition in mitochondrial translation (PubMed:27497299, PubMed:27356879)

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