ZKSCAN8: A Zinc Finger Protein with KRAB and SCAN Domains 8 (ISOFORM 1) as a Drug Target or Biomarker
ZKSCAN8: A Zinc Finger Protein with KRAB and SCAN Domains 8 (ISOFORM 1) as a Drug Target or Biomarker
Abstract:
Zinc finger proteins (ZFPs) are a family of non-coding RNAs that play crucial roles in various cellular processes. ZKSCAN8, a zinc finger protein with KRAB and SCAN domains 8 (ISOFORM 1), has been identified as a potential drug target or biomarker . Its unique structure and function make ZKSCAN8 an attractive target for drug development. This article will provide an overview of ZKSCAN8, including its structure, function, and potential as a drug target or biomarker.
Introduction:
Zinc finger proteins (ZFPs) are a family of non-coding RNAs that have been identified as key regulators in various cellular processes. These proteins often have multiple functional domains, including KRAB and SCAN domains, which contribute to their unique structure and function. ZKSCAN8 , a zinc finger protein with KRAB and SCAN domains 8 (ISOFORM 1), has been identified as a potential drug target or biomarker.
Structure and Function:
ZKSCAN8 is a 21-kDa protein that contains six zinc fingers and several non-coding RNA-binding domains. Its unique structure consists of a central nucleotide-binding domain, two KRAB domains, one SCAN domain, and a C-terminal TIR domain. The KRAB domains are responsible for the protein's nuclear localization, while the SCAN domain is involved in protein-protein interaction and regulation of gene expression.
ZKSCAN8 functions as a negative regulator of gene expression by binding to specific target genes and suppressing their translation into protein. This mechanism of regulation is similar to that of other zinc finger proteins, such as SIPR and ZNF1. ZKSCAN8 has been shown to regulate the expression of target genes involved in cell adhesion, migration, and invasion.
Potential as a Drug Target:
The unique structure and function of ZKSCAN8 make it an attractive target for drug development. Zinc finger proteins have been shown to be involved in various cellular processes, including cell adhesion, migration, and invasion, making them potential drug targets for diseases such as cancer, neurodegenerative diseases, and autoimmune disorders.
In addition to its potential as a drug target, ZKSCAN8 also has the potential as a biomarker. The regulation of gene expression by ZKSCAN8 can be used to study the effects of drugs on gene expression and protein synthesis. This can be useful for the development of new drugs, including those targeting zinc finger proteins.
Conclusion:
ZKSCAN8 is a unique zinc finger protein that has been identified as a potential drug target or biomarker. Its unique structure and function make it an attractive target for drug development, and its regulation of gene expression by Zinc finger proteins makes it a promising biomarker for drug development. Further research is needed to fully understand the function and potential of ZKSCAN8 as a drug target and biomarker.
Protein Name: Zinc Finger With KRAB And SCAN Domains 8
Functions: May be involved in transcriptional regulation
More Common Targets
ZKSCAN8P1 | ZMAT1 | ZMAT2 | ZMAT3 | ZMAT4 | ZMAT5 | ZMIZ1 | ZMIZ1-AS1 | ZMIZ2 | ZMPSTE24 | ZMYM1 | ZMYM2 | ZMYM3 | ZMYM4 | ZMYM4-AS1 | ZMYM5 | ZMYM6 | ZMYND10 | ZMYND11 | ZMYND12 | ZMYND15 | ZMYND19 | ZMYND8 | ZNF10 | ZNF100 | ZNF101 | ZNF106 | ZNF107 | ZNF112 | ZNF114 | ZNF117 | ZNF12 | ZNF121 | ZNF124 | ZNF131 | ZNF132 | ZNF133 | ZNF134 | ZNF135 | ZNF136 | ZNF137P | ZNF138 | ZNF14 | ZNF140 | ZNF141 | ZNF142 | ZNF143 | ZNF146 | ZNF148 | ZNF154 | ZNF155 | ZNF157 | ZNF16 | ZNF160 | ZNF165 | ZNF169 | ZNF17 | ZNF174 | ZNF175 | ZNF177 | ZNF18 | ZNF180 | ZNF181 | ZNF182 | ZNF184 | ZNF185 | ZNF189 | ZNF19 | ZNF195 | ZNF197 | ZNF2 | ZNF20 | ZNF200 | ZNF202 | ZNF204P | ZNF205 | ZNF205-AS1 | ZNF207 | ZNF208 | ZNF209P | ZNF211 | ZNF212 | ZNF213 | ZNF213-AS1 | ZNF214 | ZNF215 | ZNF217 | ZNF219 | ZNF22 | ZNF22-AS1 | ZNF221 | ZNF222 | ZNF223 | ZNF224 | ZNF225 | ZNF225-AS1 | ZNF226 | ZNF227 | ZNF229 | ZNF23
