CEL: A Potential Drug Target and Biomarker for Cancer and Other Diseases

Target Name: CEL

NCBI ID: G1056

CEL: A Potential Drug Target and Biomarker for Cancer and Other Diseases

CEL (CEL\\_HUMAN) is a protein that is expressed in the human body and has been shown to play a role in the development and progression of various diseases, including cancer. As a drug target or biomarker, CEL has significant potential for the development of new treatments for these diseases.

CEL is a member of the immunoglobulin superfamily and is expressed in a variety of tissues throughout the body, including the liver, spleen, and bone marrow. It is involved in the immune response and has been shown to play a role in regulating the production and function of other immune cells, such as T cells and B cells.

One of the most promising aspects of CEL is its potential as a drug target. CEL has been shown to interact with a variety of different drugs, including those that are used to treat cancer. For example, studies have shown that inhibiting the activity of CEL can lead to a reduction in the growth of cancer cells. Additionally, CEL has also been shown to interact with certain medications that are used to treat autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis.

Another potential use of CEL as a drug target is its potential as a biomarker. CEL has been shown to be expressed in a variety of diseases, including cancer, and has been used as a marker for disease progression and response to treatment. For example, studies have shown that the level of CEL is significantly increased in the blood of people with cancer, and that levels of CEL have been used as a predictor of disease outcome in some cases.

In addition to its potential as a drug target and biomarker, CEL is also of interest to researchers because of its unique structure and biology. CEL is a glycoprotein, which means that it consists of both protein and carbohydrate components. This unique structure allows it to be processed by the body's immune system and targeted to specific antigens. Additionally, CEL's structure also allows it to be expressed in a variety of different cell types, which may have important implications for its function in different tissues.

Overall, CEL has significant potential as a drug target and biomarker for the treatment of various diseases. While further research is needed to fully understand its function and potential, its unique structure and biology, as well as its potential interactions with different medications, make it an important area of study. As research continues, it is likely that the use of CEL will become increasingly important in the development of new treatments for a variety of diseases.

Protein Name: Carboxyl Ester Lipase

Functions: Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs) (PubMed:8471055, PubMed:27509211, PubMed:10220579, PubMed:27650499). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (PubMed:8471055, PubMed:27509211, PubMed:10220579, PubMed:27650499)

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