Stroke, Ischemic
About the Disease
Stroke, Ischemic, also known as cerebral infarction, is related to sneddon syndrome and brain small vessel disease 1, and has symptoms including angina pectoris, back pain and chest pain. An important gene associated with Stroke, Ischemic is F5 (Coagulation Factor V), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Diseases of hemostasis. The drugs Heparin, bovine and Nadroparin have been mentioned in the context of this disorder. Affiliated tissues include Bone and Brain, and related phenotypes are stroke and homeostasis/metabolism
Common Targets / Biomarkers
GLP1R | PTAFR | HLF | PTGS2 | CAPN2 | SENP3 | KMO | MicroRNA 4792 | KCNQ2 | F12 | MGP | CCDC159 | NLRP3 Inflammasome | MIR130B | PGAP1 | LOC105375175 | TCF7L2 | GRIN2B | NPR3 | CUBN | MIR4432 | RNLS | PM20D1 | KCNJ11 | MIRLET7I | RPS6KA4 | DNASE1 | TNFSF4 | CARD8 | ALOX15 | Acetyl-CoA Carboxylases (ACC) (nonspecified subtype) | Superoxide dismutase (SOD) (nonspecified subtype) | SLC12A2 | KLHL31 | MTHFR | Phosphodiesterase (nonspecified subtype) | CYP19A1 | CGAS | MIR149 | MMP1 | MIR4698 | GSTP1 | SCN5A | PRDX1 | HMOX1 | SCN2A | TBXAS1 | UGT1A10 | CD36 | CAT | MAS1L | PROKR2 | Glutamate Receptor Ionotropic AMPA Receptor | PROC | LINC01394 | CETP | ADK | SELE | PHACTR1 | VEGFA | ADAMTS7 | LPL | MIR150 | TNFRSF11B | P2RY1 | CASP7 | RGS7 | Prolyl 4-hydroxylase | RTN4R | LRP6 | NAPA | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | MIR320A | MTCL1 | PIK3CG | FFAR4 | Proteasome Complex | SLC9A1 | MIR323B | HRH3 | Na+/H+ Exchanger (NHE) (nonspecified subtype) | Corticotropin-Releasing Factor (CRF) Receptor (nonspecified subtype) | PLBD2 | XRCC1 | ABCB1 | CYP3A4 | VWF | CACNA1B | P2RX1 | MAPK8 | CTNNB1 | PUF60 | NTRK2 | HLA-DMA | SERPINA3 | SOD1 | EDNRA | MPO | TRAF2 | 5-Hydroxytryptamine Receptor 3 (5-HT3 receptor) (nonspecified subtype) | SRC | ATP6V0A4 | PDE4D | KCNAB2 | ADGRF1 | GPR35 | XIRP1 | XPC | GCH1 | ZPR1 | RPS6KA2 | m-Calpain | MIR200B | TLR7 | GHRL | Kainate Receptor (GluR) (nonspecified subtype) | Integrin alpha4beta1 (VLA-4) receptor | THSD4 | COMMD7 | SNORD78 | ZNF778 | NGFR | Calpain (nonspecified subtype) | IL10 | SKIC2 | LDLR | CALD1 | MIR933 | KNG1 | NOTCH3 | HP | RAC1 | HACD4 | TTR | SMG6 | GJA4 | PTPRD | Metabotropic glutamate (mGluR) receptor (nonspecified subtype) | FKBP4 | AVPR1A | TBPL1 | CAMSAP3 | Voltage-gated K(v) channel (nonspecified subtype) | XPNPEP1 | PTPRS | BDNF | ABL1 | GRIK1 | ABCA7 | PTGES | NLRP3 | ST3GAL3 | COX3 | CRBN | RYR1 | SLC18A2 | MC1R | F13A1 | HLA-DQB1 | TMCC3 | gamma-Secretase | APOA5 | CPS1 | CELF1 | IPCEF1 | NR1I3 | JCAD | CXCL8 | SRR | KCNA3 | TPP1 | BSG | TRAF3 | GRIN1 | GRM5 | GAS5 | L-type voltage-dependent calcium channel complex | CASS4 | NOS1AP | Cyclophilins (nonspecified subtype) | SFRP2 | GLIS3 | XPNPEP2 | EPHA1-AS1 | WNT2B | POR | AQP4 | ORAI1 | PTGER3 | Endothelin-Converting Enzymes (ECE) (nonspecified subtype) | IL12B | CYP2D6 | P4HA3 | ITGA2 | NUP210 | ANKS1A | SCNN1A | Tyrosine-Protein Kinases Src (nonspecified subtype) | SMO | MAPK1 | PTGIR | JAK2 | AHCY | NOS1 | P2RY2 | GNB3 | CEP170B | UBR3 | ALOX5AP | ADRA1A | CSK | Interleukin-1 (nonspecified subtype) | LGALS3 | MIR34A | ADTRP | PLA2G4A | MIR4268 | TRPV4 | Phosphodiesterase 1 (PDE1) (nonspecified subtype) | IKBKB | DRD4 | OPRK1 | MIR4277 | SLC17A3 | CYSLTR1 | SKIC3 | IL1RN | RPS6KA3 | CYP2C19 | THBS2 | FLG | TERT | FGFR2 | GP1BA | ITGA2B | TNF | DLGAP4 | C-X-C Chemokine Receptor CXCR1/CXCR2 (IL-8 Receptor) (nonspecified subtype) | VKORC1 | DGAT2 | MGLL | AGT | SLC35E1 | AVPR1B | MIR492 | LPAR1 | ADIPOQ | AMP-activated protein kinase (AMPK) | MIR155 | HDAC6 | Integrin alphavbeta3 (vitronectin) receptor | CD2AP | LOC105375733 | RTN4 | KCNQ3 | Calcium release-activated channel (CRAC) | Phospholipase A2 (nonspecified subtype) | PLCL1 | ICAM4 | IDO1 | ACSL1 | PIP5K1B | HLA-DOA | Steroid 5-alpha-Reductase (nonspecified subtype) | EPHX2 | ALOX12 | AMBP | HDAC5 | MIR494 | Hedgehog Protein (nonspecified subtype) | NTN4 | JUN | CA1 | T-Type Calcium Channel | COL4A1 | CALM1 | KCTD2 | PDE1C | MAPK11 | IMPA2 | ND1 | JMJD1C | HDAC7 | URAHP | HIF1A | APLNR | C5 | GSTO1 | MMAB | ROCK1 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | STAT3 | OPRM1 | MIR2117 | BAK1 | Heat shock protein 90 (nonspecified subtype) | MIR495 | HRH2 | CA12 | RAPGEF2 | IGFBP1 | UBE2Z | SLC22A3 | LPAL2 | CIRBP | MIR596 | SIGMAR1 | Alpha-2 Adrenergic receptors (nonspecified subtype) | MMP3 | CHRM1 | CCL5 | Ribonucleoside-diphosphate reductase | ANXA5 | IGF1 | IL-1 Receptor (nonspecified subtype) | ACE | ELANE | LOC102724428 | MIR497 | MIR122 | PINX1 | HTR4 | MED12L | CASR | CFDP1 | PLAA | MAPK12 | KCNK2 | NINJ2 | NOX4 | FLJ30679 | MIR143 | TF | ALDH2 | CASP9 | LCK | Alcohol Dehydrogenase (nonspecified subtype) | PIM3 | SPG21 | LIPA | MIR34B | LSM3 | PPARA | Integrin Receptor (nonspecified subtype) | Calcium channel (nonspecified subtype) | LTA | TRAF6 | F3 | NRF1 | GP5 | PTEN | CNR2 | IL1B | MAPK14 | MMP12 | ALPK1 | PDGFRL | TCF21 | CHFR | Lipoxygenase (nonspecified subtype) | IL4R | TGFB1 | CLU | Matrix Metalloproteinase (MMP) (nonspecified subtype) | LDHAL6A | PDE9A | CDK5 | PSMA6 | Glutamate Transporter (nonspecified subtype) | Calcium-Activated K(Ca) Potassium Channel (nonspecified subtype) | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | DHX15 | PUM1 | RHPN1 | ADD1 | CXCR1 | ADAM17 | HHIPL1 | TNFSF11 | PTGIS | Myosin Class II (nonspecified subtype) | SLC6A9 | PSRC1 | FGA | PANX1 | KEAP1 | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | MTHFD1L | SLC44A2 | IL6 | MIR605 | ESR2 | APOC3 | CYP2C8 | Opioid receptor (nonspecified subtype) | NDRG2 | Neurotrophic Factor (nonspecified subtype) | Chloride channel (nonspecified subtype) | Raf kinase (nonspecified subtype) | MVK | ZFHX3 | PRKAG2 | AVPR2 | F10 | CACNA1C | PCSK9 | Guanylate cyclase (nonspecified subtype) | HTR1A | ADORA1 | LOC650157 | TRPM8 | CELSR1 | VCAM1 | PECAM1 | LOC105374207 | HMGCR | PTPRJ | SLC6A2 | MAP2K1 | BCR | PGAM5-KEAP1-NRF2 Complex | FERMT2 | ROS1 | NFE2L2 | SIRT1 | CD14 | Adenosine deaminase (nonspecified subtype) | DRD2 | MTRR | NPPA | STAT1 | NEDD4 | NPPA-AS1 | GPX1 | KCNE1 | MASP2 | CDKN2B-AS1 | NR1I2 | CCL11 | MIR124-1 | CHRNA7 | MIR21 | EDNRB | ANAPC11 | PGR | ADA | Integrin alphaIIbbeta3 (fibrinogen gpIIb/IIIa) receptor | NF-kappaB (NFkB) | ABCA1 | CELSR2 | MIR34C | SETBP1 | HSD17B6 | ICAM1 | SELP | KCNC3 | NELFE | HLA-B | BCHE | BRAF | MECOM | CXCR4 | CCNL2 | ZCWPW1 | CASP2 | PRKCH | MAP4K4 | SLC66A3 | Estrogen receptor (nonspecified subtype) | NPPB | P2RX4 | PSKH2 | TADA2B | CYP24A1 | ZNF208 | GCKR | GABA(A) receptor | SOD2 | MEF2C-AS1 | CNR1 | GALNT17 | CCR2 | DNAH11 | GSTO2 | MYH2 | NPY | DLG4 | P4HB | MAPK9 | CES1 | Na+/K+-ATPase (nonspecified subtype) | ND3 | PPARD | IGFBP3 | STAT5 (nonspecified subtype) | TRIM71 | ABCC9 | CD40 | PTK2B | MX1 | TRIM27 | VAPA | BAX | IL15RA | LOC100130987 | PTCH1 | SLC52A3 | TRIM46 | PDE4DIP | APAF1 | 15-Lipoxygenase (nonspecified subtype) | KCNA5 | TCN2 | FGB | OXT | CPB2 | SLC19A1 | MIR210 | PLAT | SNORD81 | Amyloid beta A4 precursor protein-binding family (APP-BP) (nonspecified subtype) | Reverse transcriptase (Telomerase) | PARP1 | AKT2 | K(ATP) Channel (nonspecified subtype) | TLR4 | LHCGR | FERMT3 | PLG | HLA-DRB1 | RYR2 | P2RY12 | MIR3922 | Pyruvate dehydrogenase kinase (nonspecified subtype) | AKR1B1 | CYP2R1 | ADORA2A | LRRC26 | SYK | TSPO | FBXL7 | MIR3622A | HDAC9 | COL4A2 | SMARCA4 | MIR627 | MME | NTNG1 | FOXF2 | CASP8 | IL17A | Voltage-Gated Sodium Channel Complex | WRAP53 | WDR12 | F2 | BDNF-AS | STMN4 | MIR3679 | CXCL1 | sigma Receptor (nonspecified subtype) | Heme Oxygenase (HO) (nonspecified subtype) | Class III phosphatidylinositol 3-kinase (PI3-kinase) sub-complex | ADORA3 | CYP2J2 | Triacylglycerol Lipase (TG Lipase) (nonspecified subtype) | NTSR1 | OPRD1 | SERPINE1 | CBS | RASIP1 | ANKS1B | CHN1 | CHRM3 | TRPV1 | MIR3674 | PPP5C | CHUK | Prostanoid TP receptor (nonspecified subtype) | LRP1 | CHSY1 | SNORD80 | KCNE3 | TRPM4 | LIPC | FOLH1 | CAPN1 | GCLM | MIR499B | Integrin alpha2beta3 Receptor | XDH | PIK3C3 | TNFRSF11A | GSTT1 | OGA | LINC02210-CRHR1 | LOC105372028 | MALAT1 | TRPM2 | GSK3B | PTGS1 | PTPN1 | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | KCNE4 | ACHE | ABCG2 | HLA-A | Glycine receptor | CRYBA2 | EPOR | PPARG | NAA25 | SERPINF2 | NRXN2 | HDAC4 | F5 | CXCL2 | CYP3A5 | HNF1A | IGF1R | IL5RA | Integrin alphaLbeta2 (LFA-1) receptor | PKM | GGT1 | ASB10 | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | SST | PROKR1 | ABCC8 | MMP13 | CR1 | PAPPA | CRHR1 | PCK1 | BCAP29 | Caspase (nonspecified subtype) | ZC3HC1 | ESR1 | KCNE2 | ST3GAL4 | PDE11A | MIR4669 | KIF21A | CHI3L1 | CHRM5 | FGFR1 | EFCAB12 | RNF126 | CLK1 | TXNRD1 | FGFR4 | GABRA5 | GRM1 | RAF1 | INS | MIPOL1 | KCNJ8 | L-Type calcium channel (nonspecified subtype) | KCNQ1 | VAMP8 | Sodium channel (nonspecified subtype) | LMOD1 | PATJ | Heat shock protein 70 (nonspecified subtype) | CISD1 | LIMASI | SHH | SLC2A1 | GMDS | PTGER1 | PTGES2 | GP6 | F2RL3 | KL | Adenosine receptor (nonspecified subtype) | CYP2C9 | FLT1 | TMEM97 | A1CF | FASN | SIK2 | CASP3 | CYSLTR2 | APOA1 | SLC24A4 | VCP | CYP4F2 | ITGB3 | HIF3A | Poly [ADP-ribose] polymerase (nonspecified subtype) | MAPK10 | KCNS3 | PON1 | ACYP2 | CTCFL | SLC2A9 | SGCZ | SRSF2 | ASIC1 | ECE1 | ERCC4 | PTPN22 | SNORD47 | KCNK17 | ADAMTS2 | AP-1 Transcription Factor Complex | CYP2B6 | LINC01094 | EGLN1 | NECTIN2 | SLC22A5 | HBEGF | GLB1L | PLAU | MMP8 | BAMBI | ASIC3 | ANXA1 | IL21 | Neurotensin receptor (nonspecified subtype) | IL1A | Hypoxia-Inducible Factor Prolyl Hydroxylase (nonspecified subtype) | Muscarinic Acetylcholine Receptor (mAChR) (nonspecified subtype) | MIR126 | TBXA2R | TIMP2 | C14orf119 | ARHGEF10 | Sterol Regulatory Element-Binding Protein (nonspecified subtype) | KCNH1 | MMP9 | CDK5RAP3 | F11 | NOS3 | STK39 | Angiotensin receptor (AT) (nonspecified subtype) | LRRFIP1 | SEMA3A | VDAC2 | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | CXCR2 | PEAR1 | TACR1 | MRAS | ATF6 | SMAD3 | TP53 | RAP1B | ITPKB | SIK1 | LIPE | LTC4S | PPM1A | SORL1 | ROCK2 | CYP4A11 | MIR4520-1 | RETN | HRH1 | Endothelin receptor (nonspecified subtype) | SLC6A4 | FGG | MTHFSD | LPA | SH2B3 | MAP2K2 | NLN | CXCL16 | F7 | RUVBL2 | Calcium/calmodulin-dependent protein kinase type II (CaMK-II) | CTSB | KLKB1 | SIRT7 | PDE5A | AGTR2 | RIPK3 | Gamma-glutamyl transferase (nonspecified subtype) | WT1 | APOB | APP | AGTR1 | ND5 | CASP1 | CASP6 | alpha-Amylase (nonspecified subtype) | ITCH | LOC105379030 | HMGB1 | IL2 | NMDA receptor | MIR146A | C3 | PANK1 | PARP2 | RGMA | PON2 | AGER | ABAT | PARG | MIA3 | SPSB3 | Glutamate Receptor Ionotropic (nonspecified subtype) | NT5E | Nitric oxide synthase (NOS) (nonspecified subtype) | GPR182 | KCNA2 | PGK1 | HNF4G | NQO1 | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | MMP2 | MYH7B | DNAH14 | CNNM2 | IRAG1 | JMY | AR | NLGN1 | Na+/Ca2+ Exchanger (NCX) (nonspecified subtype) | TERC | MET | ABCC1 | MS4A2 | PDE1A | P4HA2 | PLPP3 | MIR6843 | KRR1 | CYP2C18 | MYO5B | CCL2 | CRP | CX3CR1 | SLC8A1 | CYP11B2 | SLC1A2 | Mitogen-activated protein kinase (JNK) (nonspecified subtype) | SVIL | HTR2A | RPS6KA5 | PTPN11 | MIR196A2 | PIK3CA | TLR4/MD-2 complex | ADGRA2 | VAV3 | PRNP | MIR130A | GSTM1 | TAOK1 | ADH1C | ITPR1 | LTA4H | FCER1G | TRPA1 | Potassium Channels (nonspecified subtype) | VDR | LY96 | GLA | ECE2 | Rho kinase (ROCK) (nonspecified subtype) | OR2B6 | LINC00494 | KCNB1 | RIPK1 | Epoxide Hydrolase (nonspecified subtype) | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | RPS6KA1 | NOS2 | TLR9 | GNAZ | TERF1 | UCP2 | LLGL2 | OXTR | ALOX5 | LIPG | MIR499A | CCR5 | IL21R | MIR300 | SLC22A11 | INPP5D | S1PR1 | PDGFRA | mu-Calpain (calpain 1) | RHOA | VHL | SETD7 | EGLN3 | APOE | SHMT1 | SLC6A3 | MAOB | NGF
Other Diseases
Stromal Corneal Dystrophy | Sturge-Weber Syndrome | Stuttering | Stuve-Wiedemann Syndrome | Subacute Sclerosing Panencephalitis | Subcortical Band Heterotopia | Succinic Semialdehyde Dehydrogenase Deficiency | Sulfite Oxidase Deficiency | Superficial Spreading Melanoma | Supravalvular Aortic Stenosis | Sweet Syndrome | Swine Influenza | Syncope | Syndactyly | Synovitis | Synpolydactyly | Syphilis | Systemic Lupus Erythematosus | Systemic Mastocytosis | T-cell Chronic Lymphocytic Leukemia | T-cell Leukemia | T-cell Lymphoma, Subcutaneous Panniculitis-like | T-cell Prolymphocytic Leukemia | Takayasu's Arteritis | Takenouchi-Kosaki Syndrome | Takotsubo Cardiomyopathy | Tangier Disease | Tardive Dyskinesia | TARP Syndrome | Tatton-Brown-Rahman Syndrome | Tay-Sachs Disease | Temporal Lobe Epilepsy | Temtamy Preaxial Brachydactyly Syndrome | Tendinitis | Tendinopathy | Tenosynovial Giant Cell Tumor | Teratozoospermia | Tetanus | Thalassemia | Thalassemia, Beta | Thanatophoric Dysplasia | Thanatophoric Dysplasia Type 1 | Thin Basement Membrane Disease | Thrombasthenia | Thrombocythemia, Essential | Thrombocytopenia | Thromboembolism | Thrombophilia | Thrombophlebitis | Thrombosis | Thrombotic Microangiopathy | Thymoma, Malignant | Thyroid Dysgenesis | Thyroid Dyshormonogenesis | Thyroid Hormone Resistance | Thyroiditis | Thyroiditis, Autoimmune | Thyrotoxic Periodic Paralysis | Tibial Muscular Dystrophy | Tic Disorder | Tietze Syndrome | Tinea | Tinea Versicolor | Tonsillitis | Torticollis | Toxic Epidermal Necrolysis | Toxoplasmosis | Traboulsi Syndrome | Tracheal Disorders | Trachoma | Transcobalamin Deficiency | Transient Bullous Dermolysis Of The Newborn | Transthyretin-related Amyloidosis | Treacher Collins Syndrome | Tremor | Tricho-hepato-enteric Syndrome | Trichomegaly | Trichorhinophalangeal Syndrome | Trichothiodystrophy | Trichotillomania | Trichuriasis | Trigonocephaly | Trimethylaminuria | Triphalangeal Thumb-polysyndactyly Syndrome | Triple A Syndrome | Trismus-pseudocamptodactyly Syndrome | Tuberculosis | Tuberculous Meningitis | Tularemia | Tumoral Calcinosis | Turner's Syndrome | Twin-to-twin Transfusion Syndrome | Tylosis With Esophageal Cancer | Tyrosine Hydroxylase Deficiency | Tyrosinemia | Tyrosinemia Type 1 | Tyrosinemia Type 2 | Ulcerative Colitis | Unverricht-Lundborg Syndrome | Urea Cycle Disorder | Uremia | Uremic Pruritus | Ureteropelvic Junction Obstruction | Urethritis | Urofacial Syndrome | Urolithiasis | Urticaria | Usher Syndrome | Usher Syndrome Type II | Usher Syndrome Type IIC | Usher Syndrome Type III | Uterine Leiomyoma | Uveitis | Uveitis, Anterior | VACTERL Association | VACTERL/VATER Association | Vaginitis | Van Der Knaap Disease | Varicocele | Vascular Calcification | Vascular Cognitive Impairment | Vasculitis | Veno-occlusive Disease | Venous Insufficiency | Ventricular Septal Defect | Vertebrobasilar Insufficiency | Vertigo | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Vestibular Disease | VEXAS Syndrome | Vici Syndrome | Viral Meningitis | Vitamin A Deficiency | Vitamin B12 Deficiency | Vitamin D Deficiency | Vitamin K Deficiency | Vitelliform Macular Dystrophy | Vitiligo | Vitreoretinal Degeneration, Snowflake Type | Vitreoretinopathy, Proliferative | Vogt-Koyanagi-Harada Syndrome | Von Hippel-Lindau Disease | Von Willebrand Disease | Vulvovaginitis | Waardenburg Syndrome | Waardenburg Syndrome Type 1 | Waardenburg Syndrome Type 2 | Waardenburg Syndrome Type 2A | Waardenburg Syndrome Type 2E | Waardenburg Syndrome Type 4 | Waardenburg Syndrome Type 4A | Wagner Disease | WAGR Syndrome | Waldenstrom Macroglobulinemia | Walker-Warburg Syndrome | Warsaw Breakage Syndrome | Weill-Marchesani Syndrome | Werner's Syndrome | Whipple's Disease | Wieacker-Wolff Syndrome | Wiedemann-Steiner Syndrome | Williams Syndrome | Wilson's Disease | Wiskott-Aldrich Syndrome | Withdrawal Syndrome | Wolcott-Rallison Syndrome | Wolff-Parkinson-White Syndrome | Wolfram Syndrome | Wolfram Syndrome 2 | Wolman Disease | Woodhouse-Sakati Syndrome | X-linked Acrogigantism | X-linked Charcot-Marie-Tooth Disease | X-linked Creatine Transporter Deficiency | X-linked Myotubular Myopathy | X-linked Sideroblastic Anemia | Xeroderma Pigmentosum | Xeroderma Pigmentosum Variant Type | Yellow Fever | Zellweger Syndrome | Zimmermann-Laband Syndrome | Zollinger-Ellison Syndrome | Zygomycosis
