Studies Suggest ZBTB43 as Potential Drug Target for Various Diseases

Target Name: ZBTB43

NCBI ID: G23099

Studies Suggest ZBTB43 as Potential Drug Target for Various Diseases

ZBTB43 (KIAA0414) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the T-cell antigen 6 (TCA6) family, which is characterized by the presence of a variable region of the protein that contains a GXXGDKXX motif. ZBTB43 is also known as CD28, and it has been shown to play a role in various cellular processes, including T cell activation, immune surveillance, and neuroprotection.

Recent studies have suggested that ZBTB43 may be a drug target (or biomarker) due to its involvement in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. ZBTB43 has also been shown to interact with various molecules, including T cell factor 4 (TCF-4), which is a critical regulator of T cell development and function.

One of the key functions of ZBTB43 is its role in T cell development and activation. T cells are a critical immune cell that play a vital role in protecting the body against infection and disease. ZBTB43 has been shown to be involved in T cell activation and proliferation, as well as in the regulation of T cell death.

In addition to its role in T cell development and regulation, ZBTB43 has also been shown to be involved in the regulation of immune surveillance. ZBTB43 has been shown to interact with various immune molecules, including CD11b, which is a critical receptor for immune cells on the surface of immune cells. This interaction between ZBTB43 and CD11b has been shown to play a role in immune surveillance, as well as in the regulation of autoimmune diseases.

ZBTB43 has also been shown to be involved in the regulation of neuroprotection. Neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, are characterized by the progressive loss of brain cells and the development of neurofibrillary tangles. ZBTB43 has been shown to be involved in the regulation of neuroprotection, as well as in the development and progression of these diseases.

In conclusion, ZBTB43 is a protein that has been shown to play a role in various cellular processes, including T cell activation, immune surveillance, and neuroprotection. Its interaction with T cell factor 4 (TCF-4) has also suggested that it may be a drug target (or biomarker) for various diseases. Further research is needed to fully understand the role of ZBTB43 in these processes and to develop effective treatments for these diseases.

Protein Name: Zinc Finger And BTB Domain Containing 43

Functions: May be involved in transcriptional regulation

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