ZC3H1C: Key Regulator of Cell Processes (G51530)

Target Name: ZC3HC1

NCBI ID: G51530

ZC3H1C: Key Regulator of Cell Processes

ZC3H1C (ZC3C1_HUMAN), also known as ZC3A, is a protein that is expressed in various tissues of the human body. It is a key regulator of cell proliferation and has been implicated in many diseases, including cancer.

One of the key functions of ZC3H1C is its role in the regulation of the G1/S transition, which is the process by which cells move from the G1 phase (cell cycle) to the S phase (G2 phase). During the G1/S transition, cells prepare for cell division by producing more DNA and increasing their size. ZC3H1C is known to play a crucial role in regulating the size and number of chromosomes in the S phase, which is essential for cell division.

In addition to its role in cell proliferation, ZC3H1C has also been shown to be involved in the regulation of cell survival and the development of cancer. Studies have shown that high levels of ZC3H1C are associated with poor prognosis in many types of cancer, including breast , ovarian, and prostate cancers.

Another function of ZC3H1C is its role in the regulation of cell migration. Research shows that ZC3H1C plays a key role in the migration of cancer cells to new sites of infection or tumors. This is important because cancer cells can only spread to other parts of the body if they are able to leave the original site of the tumor and travel to a new location.

In addition to its role in cell proliferation, migration, and survival, ZC3H1C is also involved in the regulation of cell adhesion. Adhesion is the process by which cells stick together to form tissues and organs. ZC3H1C is known to play a crucial role in the regulation of cell adhesion, which is essential for the development and maintenance of tissues and organs.

Overall, ZC3H1C is a protein that has important functions in the regulation of cell proliferation, survival, migration, and adhesion. Its role in these processes makes it an attractive target for drug development. Currently, there are several ZC3H1C-based drugs that are being developed for the treatment of various diseases, including cancer. These drugs work by inhibiting the activity of ZC3H1C and preventing it from regulating the cell cycle, migration, and adhesion.

In conclusion, ZC3H1C is a protein that has important functions in the regulation of cell proliferation, survival, migration, and adhesion. Its role in these processes makes it an attractive target for drug development. Currently, there are several ZC3H1C-based drugs that are being developed for the treatment of various diseases, including cancer. These drugs work by inhibiting the activity of ZC3H1C and preventing it from regulating the cell cycle, migration, and adhesion. Further research is needed to fully understand the role of ZC3H1C in the regulation of cell processes and its potential as a drug target.

Protein Name: Zinc Finger C3HC-type Containing 1

Functions: Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events

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