ZFPM2-AS1: A Potential Drug Target and Biomarker (G102723356)
ZFPM2-AS1: A Potential Drug Target and Biomarker
ZFPM2-AS1, a non-coding RNA molecule located in the Z-factor chromatin-remodeling complex (ZCRS), has been identified as a potential drug target and biomarker for various diseases. ZCRS is a key regulator of chromatin remodeling, which plays a critical role in the regulation of gene expression and cellular processes. The ZFPM2 gene encodes a protein that is involved in the formation of the ZCRS complex, which consists of various proteins that work together to modify the chromatin structure and gene expression. ZFPM2-AS1 has been shown to play a crucial role in the regulation of gene expression and has been associated with various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.
The ZFPM2-AS1 gene has four exons, and the protein encoded by this gene is a 24.5 kilobase (kb) long transcript that has been shown to play a critical role in the regulation of gene expression in various organisms. ZFPM2-AS1 has been shown to interact with various proteins, including the transcription factor ASXL1, which is known to play a crucial role in the regulation of gene expression and has been implicated in various diseases, including cancer.
One of the most significant studies demonstrating the potential of ZFPM2-AS1 as a drug target was published in the journal Nature in 2018. In this study, researchers identified a link between ZFPM2-AS1 and the development of neurodegenerative diseases, specifically in the context of a neurodegenerative disease called ALS (Amyotrophic Lateral Sclerosis). The researchers found that individuals with the ZFPM2-AS1 gene had an increased risk of developing ALS and that the ZFPM2-AS1 protein was significantly overexpressed in individuals with ALS. The researchers also found that treatment with a drug that inhibited the activity of ZFPM2-AS1, a small molecule called 5-lipoxygenase (5-LO), significantly reduced the risk of developing ALS in ZFPM2-AS1-null mice.
In addition to its potential as a drug target, ZFPM2-AS1 has also been shown to be a potential biomarker for various diseases. For example, the researchers identified ZFPM2-AS1 as significantly overexpressed in individuals with cancer and found that ZFPM2-AS1 levels were correlated with the size of primary tumors. The researchers also found that ZFPM2-AS1 was significantly overexpressed in individuals with neurodegenerative diseases, including ALS, and that these individuals had reduced levels of the protein compared to individuals without the disease.
The potential utility of ZFPM2-AS1 as a drug target and biomarker is significant, as it has the potential to lead to new treatments for a variety of diseases. ZFPM2-AS1 has been shown to play a crucial role in the regulation of gene expression and has been associated with various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. The identification of ZFPM2-AS1 as a potential drug target and biomarker has the potential to lead to new treatments for these diseases and improve our understanding of the underlying mechanisms of these conditions.
In conclusion, ZFPM2-AS1 is a non-coding RNA molecule that has been identified as a potential drug target and biomarker for various diseases. The ZFPM2-AS1 gene has been shown to play a crucial role in the regulation of gene expression and has been associated with various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Further research is needed to fully understand the potential utility of ZFPM2-AS1 as a drug
Protein Name: ZFPM2 Antisense RNA 1
More Common Targets
ZFR | ZFR2 | ZFTA | ZFTRAF1 | ZFX | ZFX-AS1 | ZFY | ZFYVE1 | ZFYVE16 | ZFYVE19 | ZFYVE21 | ZFYVE26 | ZFYVE27 | ZFYVE28 | ZFYVE9 | ZFYVE9P1 | ZG16 | ZG16B | ZGLP1 | ZGPAT | ZGRF1 | ZHX1 | ZHX1-C8orf76 | ZHX2 | ZHX3 | ZIC1 | ZIC2 | ZIC3 | ZIC4 | ZIC5 | ZIK1 | ZIM2 | ZIM3 | Zinc finger protein GLI | ZKSCAN1 | ZKSCAN2 | ZKSCAN3 | ZKSCAN4 | ZKSCAN5 | ZKSCAN7 | ZKSCAN8 | ZKSCAN8P1 | ZMAT1 | ZMAT2 | ZMAT3 | ZMAT4 | ZMAT5 | ZMIZ1 | ZMIZ1-AS1 | ZMIZ2 | ZMPSTE24 | ZMYM1 | ZMYM2 | ZMYM3 | ZMYM4 | ZMYM4-AS1 | ZMYM5 | ZMYM6 | ZMYND10 | ZMYND11 | ZMYND12 | ZMYND15 | ZMYND19 | ZMYND8 | ZNF10 | ZNF100 | ZNF101 | ZNF106 | ZNF107 | ZNF112 | ZNF114 | ZNF117 | ZNF12 | ZNF121 | ZNF124 | ZNF131 | ZNF132 | ZNF133 | ZNF134 | ZNF135 | ZNF136 | ZNF137P | ZNF138 | ZNF14 | ZNF140 | ZNF141 | ZNF142 | ZNF143 | ZNF146 | ZNF148 | ZNF154 | ZNF155 | ZNF157 | ZNF16 | ZNF160 | ZNF165 | ZNF169 | ZNF17 | ZNF174 | ZNF175
