Target Name: ZIC3
NCBI ID: G7547
Other Name(s): Zinc finger protein 203 | HTX | zinc finger protein of the cerebellum 3 | ZIC3 variant 1 | Zinc finger protein ZIC 3 | Zinc finger protein ZIC 3 (isoform 1) | Zic family member 3 | zinc finger protein 203 | ZNF203 | Zic family member 3 (odd-paired Drosophila homolog, heterotaxy 1) | HTX1 | Zic family member 3 (odd-paired homolog, Drosophila) | ZIC3_HUMAN | Zinc finger protein of the cerebellum 3 | VACTERLX | heterotaxy 1 | Zic family member 3, transcript variant 1

Exploring The Biology of ZIC3: A Potential Drug Target and Biomarker

Zinc finger proteins (ZFPs) are a family of non-coding RNAs that play a crucial role in various cellular processes. ZIC3, also known as Zinc finger protein 203, is a ZFP that has been identified as a potential drug target and biomarker. In In this article, we will explore the biology of ZIC3 and its potential as a drug target.

The Zinc finger protein 203 (ZIC3) is a 21 kDa protein that is expressed in various tissues, including brain, heart, and muscle. ZIC3 is composed of a unique nucleotide-rich region, a transmembrane region, and a cytoplasmic tail region. The The nucleotide-rich region is the largest portion of the protein and is responsible for its unique structure.

The nucleotide-rich region of ZIC3 consists of a repeated sequence of adenine (A) nucleotides, which are followed by a series of thymine (T) nucleotides. This repeated sequence is known as the \"Zinc finger\" and is the hallmark of ZFPs. The Zinc finger region is responsible for the protein's unique structure and function.

ZIC3 has been shown to play a role in various cellular processes. For example, ZIC3 has been shown to be involved in cell signaling, specifically in the regulation of cell proliferation and differentiation. ZIC3 has also been shown to be involved in the regulation of cell migration and the development of cancer.

In addition to its role in cell signaling, ZIC3 has also been shown to be involved in the regulation of gene expression. ZIC3 has been shown to interact with various transcription factors, including transcription factor-DNA binding domain (T-DBD) factors. This interaction between ZIC3 and T-DBD factors allows ZIC3 to regulate the expression of target genes.

The potential drug target status of ZIC3 is supported by several studies. First, a bioinformatics analysis of the ZIC3 gene revealed that it has high homology with known drug targets, including the nuclear receptor subfamily 1 (NRS) gene. Second, a cellular assay using ZIC3 knockdown cells showed that ZIC3 can modulate the activity of known drug targets, including the NRS gene. Third, a chemical screening experiment identified a potential small molecule inhibitor of ZIC3 that showed partial inhibition of NRS gene activation.

The potential clinical applications of ZIC3 as a drug target are vast. First, ZIC3 has been shown to be involved in various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Second, ZIC3 has been shown to be a potential biomarker for disease diagnosis and monitoring. For example, ZIC3 has been shown to be elevated in the brains of patients with Alzheimer's disease, and it has also been used as a biomarker for evaluating the effectiveness of anti-inflammatory treatments.

In conclusion, ZIC3 is a unique and highly conserved protein that has been shown to play a role in various cellular processes. The nucleotide-rich region and the interaction with T-DBD factors make ZIC3 a potential drug target. The potential clinical applications of ZIC3 as a drug target and biomarker are vast and continue to be explored. Further research is needed to fully understand the biology of ZIC3 and its potential as a drug.

Protein Name: Zic Family Member 3

Functions: Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'

More Common Targets

ZIC4 | ZIC5 | ZIK1 | ZIM2 | ZIM3 | Zinc finger protein GLI | ZKSCAN1 | ZKSCAN2 | ZKSCAN3 | ZKSCAN4 | ZKSCAN5 | ZKSCAN7 | ZKSCAN8 | ZKSCAN8P1 | ZMAT1 | ZMAT2 | ZMAT3 | ZMAT4 | ZMAT5 | ZMIZ1 | ZMIZ1-AS1 | ZMIZ2 | ZMPSTE24 | ZMYM1 | ZMYM2 | ZMYM3 | ZMYM4 | ZMYM4-AS1 | ZMYM5 | ZMYM6 | ZMYND10 | ZMYND11 | ZMYND12 | ZMYND15 | ZMYND19 | ZMYND8 | ZNF10 | ZNF100 | ZNF101 | ZNF106 | ZNF107 | ZNF112 | ZNF114 | ZNF117 | ZNF12 | ZNF121 | ZNF124 | ZNF131 | ZNF132 | ZNF133 | ZNF134 | ZNF135 | ZNF136 | ZNF137P | ZNF138 | ZNF14 | ZNF140 | ZNF141 | ZNF142 | ZNF143 | ZNF146 | ZNF148 | ZNF154 | ZNF155 | ZNF157 | ZNF16 | ZNF160 | ZNF165 | ZNF169 | ZNF17 | ZNF174 | ZNF175 | ZNF177 | ZNF18 | ZNF180 | ZNF181 | ZNF182 | ZNF184 | ZNF185 | ZNF189 | ZNF19 | ZNF195 | ZNF197 | ZNF2 | ZNF20 | ZNF200 | ZNF202 | ZNF204P | ZNF205 | ZNF205-AS1 | ZNF207 | ZNF208 | ZNF209P | ZNF211 | ZNF212 | ZNF213 | ZNF213-AS1 | ZNF214 | ZNF215 | ZNF217