Target Name: ZKSCAN3
NCBI ID: G80317
Other Name(s): Zinc finger protein 309 | dJ874C20.1. | ZKSCAN3 variant 2 | Zinc finger protein zfp47 | ZNF306 | zfp-47 | zinc finger and SCAN domain-containing protein 13 | ZF47 | Zinc finger with KRAB and SCAN domains 3 | Zinc finger protein 47 homolog | ZSCAN35 | Zinc finger and SCAN domain-containing protein 13 | zinc finger protein 47 homolog | Zinc finger protein with KRAB and SCAN domains 3 | Zfp-47 | Zf47 | zinc finger with KRAB and SCAN domains 3 | zinc finger protein 306 | ZFP306 | zinc finger protein zfp47 | Zfp47 | ZNF309 | ZKSC3_HUMAN | Zinc finger protein 306 | dJ874C20.1 | Zinc finger with KRAB and SCAN domains 3, transcript variant 2 | ZSCAN13 | zinc finger protein 309 | Zinc finger protein with KRAB and SCAN domains 3 (isoform 1) | DJ874C20.1

ZKSCAN3: A Potential Cancer Drug Target and Biomarker

Zinc finger proteins (ZFPs) are a family of non-coding RNAs that play a crucial role in various cellular processes. ZKSCAN3, also known as Zinc finger protein 309, is a ZFP that is expressed in various tissues and has been shown to play important roles in various biological processes, including cell signaling, DNA replication, and gene expression.

One of the unique features of ZKSCAN3 is its ability to interact with other proteins, particularly with the protein p21. P21, also known as the tumor suppressor protein T-cell kinase, is a transcription factor that plays a critical role in regulating cell growth and apoptosis. ZKSCAN3 has been shown to interact with p21 and to regulate its activity.

This interaction between ZKSCAN3 and p21 raises the possibility that ZKSCAN3 may be a drug target or biomarker for cancer treatment. By inhibiting the activity of p21, researchers may be able to reduce the growth and spread of cancer cells.

In addition to its potential as a drug target, ZKSCAN3 has also been shown to be a potential biomarker for cancer. The expression of ZKSCAN3 has been shown to be elevated in various types of cancer, including breast, ovarian, and colorectal cancers. This suggests that ZKSCAN3 may be a useful diagnostic or predictive marker for these diseases.

The structure and function of ZKSCAN3 are also of interest from a fundamental biological perspective. ZKSCAN3 is a member of the Zinc finger gene family, which includes over 200 known ZFPs. Zinc finger proteins are characterized by the presence of a zinc finger motif, which consists of a series of amino acids that are similar to a zinc finger protein. This motif is thought to be a common feature of ZFPs and is involved in their functions.

The Zinc finger protein 309 gene has also been studied extensively, and several studies have investigated its function in various biological processes. For example, one study published in the journal PLoS ONE found that ZKSCAN3 was involved in cell signaling and that it interacted with the protein F-box protein 1 (FBP1). The authors suggested that ZKSCAN3 may be a new target for small molecule inhibitors of cancer.

Another study published in the journal Oncogene investigated the role of ZKSCAN3 in DNA replication and found that it was involved in the regulation of DNA replication in various cell types. The authors suggested that ZKSCAN3 may be a useful target for inhibitors of DNA replication in cancer.

In conclusion, ZKSCAN3 is a unique ZFP that has been shown to interact with the protein p21 and to regulate its activity. The potential drug target and biomarker properties of ZKSCAN3 make it an attractive target for further investigation. Further studies are needed to fully understand its role in various biological processes and to develop effective treatments for cancer.

Protein Name: Zinc Finger With KRAB And SCAN Domains 3

Functions: Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas

More Common Targets

ZKSCAN4 | ZKSCAN5 | ZKSCAN7 | ZKSCAN8 | ZKSCAN8P1 | ZMAT1 | ZMAT2 | ZMAT3 | ZMAT4 | ZMAT5 | ZMIZ1 | ZMIZ1-AS1 | ZMIZ2 | ZMPSTE24 | ZMYM1 | ZMYM2 | ZMYM3 | ZMYM4 | ZMYM4-AS1 | ZMYM5 | ZMYM6 | ZMYND10 | ZMYND11 | ZMYND12 | ZMYND15 | ZMYND19 | ZMYND8 | ZNF10 | ZNF100 | ZNF101 | ZNF106 | ZNF107 | ZNF112 | ZNF114 | ZNF117 | ZNF12 | ZNF121 | ZNF124 | ZNF131 | ZNF132 | ZNF133 | ZNF134 | ZNF135 | ZNF136 | ZNF137P | ZNF138 | ZNF14 | ZNF140 | ZNF141 | ZNF142 | ZNF143 | ZNF146 | ZNF148 | ZNF154 | ZNF155 | ZNF157 | ZNF16 | ZNF160 | ZNF165 | ZNF169 | ZNF17 | ZNF174 | ZNF175 | ZNF177 | ZNF18 | ZNF180 | ZNF181 | ZNF182 | ZNF184 | ZNF185 | ZNF189 | ZNF19 | ZNF195 | ZNF197 | ZNF2 | ZNF20 | ZNF200 | ZNF202 | ZNF204P | ZNF205 | ZNF205-AS1 | ZNF207 | ZNF208 | ZNF209P | ZNF211 | ZNF212 | ZNF213 | ZNF213-AS1 | ZNF214 | ZNF215 | ZNF217 | ZNF219 | ZNF22 | ZNF22-AS1 | ZNF221 | ZNF222 | ZNF223 | ZNF224 | ZNF225 | ZNF225-AS1