Target Name: ZKSCAN2
NCBI ID: G342357
Other Name(s): zinc finger and SCAN domain containing 31 | zinc finger with KRAB and SCAN domains 2 | ZSCAN34 | Zinc finger and SCAN domain containing 31 | Zinc finger with KRAB and SCAN domains 2 | ZNF694 | ZKSC2_HUMAN | zinc finger protein 694 | ZSCAN31 | Zinc finger protein 694 | Zinc finger protein with KRAB and SCAN domains 2

ZKSCAN2: A Potential Drug Target and Biomarker

Introduction

Zinc finger and SCAN domain-containing proteins play a crucial role in various cellular processes, including DNA replication, gene expression, and cell signaling. ZKSCAN2, a member of the Zinc Finger and SCAN Domain containing 31 family, has been identified as a potential drug target and biomarker. In this article, we will explore the molecular mechanisms of ZKSCAN2 and its potential as a drug target.

Molecular Mechanisms of ZKSCAN2

ZKSCAN2 is a 25 kDa protein that contains a zinc finger and a SCAN domain. The zinc finger domain consists of a conserved core and a variable region that contains a ligand binding site (PBD) and a zinc finger domain (ZFD ). The SCAN domain is a short, conserved sequence that contains a single strand of beta-helices.

The ZKSCAN2 protein is a non-coding RNA molecule that is expressed in various tissues and cells. It is highly conserved in its amino acid sequence, with only minor differences between the various isoforms. ZKSCAN2 is primarily localized to the cytoplasm of the cell and is involved in various cellular processes, including DNA replication, gene expression, and cell signaling.

Potential Drug Targets

ZKSCAN2 has been identified as a potential drug target due to its unique structure and various cellular processes. One of the key reasons for its potential as a drug target is its conserved nature, which suggests that it is unlikely to have a significant number of genetic variants that can be targeted by small molecules. Additionally, the zinc finger and SCAN domains of ZKSCAN2 have been shown to play important roles in various cellular processes, which makes them potential drug targets.

ZKSCAN2 has been shown to play a role in regulating gene expression and DNA replication. For instance, ZKSCAN2 has been shown to interact with the protein camouflage (SPOP) gene, which encodes a protein that can repress gene expression. This interaction between ZKSCAN2 and SPOP suggests that ZKSCAN2 may be a useful drug target for treating genetic disorders that are characterized by over-expression of SPOP-mediated gene repression.

Another potential drug target for ZKSCAN2 is its role in DNA replication. ZKSCAN2 has been shown to interact with the protein Pluto (TPM) complex, which is involved in regulating DNA replication. This interaction between ZKSCAN2 and TPM suggests that ZKSCAN2 may be a useful drug target for treating DNA replication-related disorders.

In addition to its potential role in gene expression and DNA replication, ZKSCAN2 has also been shown to play a role in cell signaling. For instance, ZKSCAN2 has been shown to interact with the protein FAK, which is involved in cell signaling. This interaction between ZKSCAN2 and FAK suggest that ZKSCAN2 may be a useful drug target for treating signaling-related disorders.

Biomarker Potential

The potential use of ZKSCAN2 as a biomarker for various diseases has also been explored. ZKSCAN2 has been shown to be highly expressed in various tissues and cells, including the brain, heart, and liver. This suggests that it may be a useful biomarker for tracking diseases that affect these tissues. Additionally, the conserved nature of ZKSCAN2 between different isoforms suggests that it is unlikely to have a significant number of genetic variants that can be used as biomarkers.

Conclusion

In conclusion, ZKSCAN2 is a unique protein that has conserved structure and function across various isoforms. Its conserved nature, as well as its role in various cellular processes, makes it a potential drug target and biomarker. Further research is needed to fully understand the molecular mechanisms of ZKSCAN2 and its potential as a drug

Protein Name: Zinc Finger With KRAB And SCAN Domains 2

Functions: May be involved in transcriptional regulation

More Common Targets

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