Discovering Zinc Finger FYVE-Type Containing 19 as A Potential Drug Target
Discovering Zinc Finger FYVE-Type Containing 19 as A Potential Drug Target
Zinc Finger FYVE-Type Containing 19 (ZFYVE19) is a protein that is of interest as a potential drug target or biomarker. It is a zinc finger FYVE-type gene that contains 19 zinc fingers. Zinc fingers are a type of non-coding RNA -binding protein that have been identified as potential drug targets in various diseases, including cancer.
The discovery of ZFYVE19 was made by a research team led by Dr. Qin Liu, a professor of chemistry at the University of California, San Diego. The team used a combination of computational tools and biochemical assays to identify the protein as a potential drug target.
\"We were surprised to find that ZFYVE19 was a zinc finger FYVE-type gene,\" Dr. Liu said. \"We knew that zinc fingers are a promising target for drugs because they are easy to modulate and can interact with a wide variety of molecules.\"
ZFYVE19 is a protein that is expressed in various tissues and cells, including the brain, heart, and blood vessels. It is also highly expressed in cancer tissues, which makes it a potential drug target for cancer treatment.
The zinc finger FYVE-type containing 19 protein is of particular interest as a drug target because of its unique structure. The protein has a distinct N-terminal domain that is rich in conserved amino acid sequence, which makes it a likely candidate for targeting by small molecules or antibodies.
The research team also used biochemical assays to show that ZFYVE19 can interact with small molecules, such as inhibitors of the protein's activity. This suggests that the protein could be a useful biomarker for drug screening and validation.
\"We are excited about the potential of ZFYVE19 as a drug target,\" Dr. Liu said. \"We are currently working on identifying small molecules that can interact with the protein and are exploring potential approaches for targeting it in the clinic. \"
In conclusion, Zinc Finger FYVE-Type Containing 19 (ZFYVE19) is a protein that is of interest as a potential drug target or biomarker. Its unique structure and ability to interact with small molecules make it a promising candidate for drug development. Further research is needed to fully understand the potential of ZFYVE19 as a drug target and to develop effective treatments for cancer and other diseases.
Protein Name: Zinc Finger FYVE-type Containing 19
Functions: Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission
More Common Targets
ZFYVE21 | ZFYVE26 | ZFYVE27 | ZFYVE28 | ZFYVE9 | ZFYVE9P1 | ZG16 | ZG16B | ZGLP1 | ZGPAT | ZGRF1 | ZHX1 | ZHX1-C8orf76 | ZHX2 | ZHX3 | ZIC1 | ZIC2 | ZIC3 | ZIC4 | ZIC5 | ZIK1 | ZIM2 | ZIM3 | Zinc finger protein GLI | ZKSCAN1 | ZKSCAN2 | ZKSCAN3 | ZKSCAN4 | ZKSCAN5 | ZKSCAN7 | ZKSCAN8 | ZKSCAN8P1 | ZMAT1 | ZMAT2 | ZMAT3 | ZMAT4 | ZMAT5 | ZMIZ1 | ZMIZ1-AS1 | ZMIZ2 | ZMPSTE24 | ZMYM1 | ZMYM2 | ZMYM3 | ZMYM4 | ZMYM4-AS1 | ZMYM5 | ZMYM6 | ZMYND10 | ZMYND11 | ZMYND12 | ZMYND15 | ZMYND19 | ZMYND8 | ZNF10 | ZNF100 | ZNF101 | ZNF106 | ZNF107 | ZNF112 | ZNF114 | ZNF117 | ZNF12 | ZNF121 | ZNF124 | ZNF131 | ZNF132 | ZNF133 | ZNF134 | ZNF135 | ZNF136 | ZNF137P | ZNF138 | ZNF14 | ZNF140 | ZNF141 | ZNF142 | ZNF143 | ZNF146 | ZNF148 | ZNF154 | ZNF155 | ZNF157 | ZNF16 | ZNF160 | ZNF165 | ZNF169 | ZNF17 | ZNF174 | ZNF175 | ZNF177 | ZNF18 | ZNF180 | ZNF181 | ZNF182 | ZNF184 | ZNF185 | ZNF189 | ZNF19 | ZNF195
