Target Name: ZFHX3
NCBI ID: G463
Other Name(s): zinc finger homeobox 3 | ZFHX3 variant A | Zinc finger homeobox 3, transcript variant A | AT motif-binding factor 1 | ZNF927 | Zinc finger homeobox protein 3 | Zinc finger homeobox 3, transcript variant B | zinc finger homeodomain protein 3 | Zinc finger homeodomain protein 3 | ATBF1 | alpha-fetoprotein enhancer binding protein | Zinc finger homeobox protein 3 (isoform B) | alpha-Fetoprotein enhancer-binding protein | C16orf47 | Alpha-fetoprotein enhancer-binding protein | Zinc finger homeobox protein 3 (isoform A) | ZFHX3_HUMAN | AT-binding transcription factor 1 | AT motif-binding factor | alpha-Fetoprotein enhancer binding protein | Alpha-fetoprotein enhancer binding protein | ZFHX3 variant B | ZFH-3 | ATBT

Zinc Finger Homeobox 3: Potential Drug Target and Biomarker

Zinc Finger Homeobox 3 (ZFHX3) is a protein that is expressed in various tissues throughout the body. It plays a crucial role in cell signaling and is involved in the development, maintenance, and regulation of tissues. ZFHX3 has also been identified as a potential drug target and biomarker for several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

The zinc finger gene is a family of transmembrane proteins that contain a conserved zinc finger domain. This domain is responsible for the protein's unique structure and function. ZFHX3 is a member of the zinc finger gene family and is expressed in various tissues, including muscle, nerve, heart, and blood vessels.

ZFHX3 is involved in several cellular processes that are essential for normal tissue development and maintenance. It is a transcription factor that regulates the expression of other genes, and it has been shown to play a role in the development and maintenance of tissues such as muscles, bones, and heart.

One of the most significant functions of ZFHX3 is its role in cell signaling. It is involved in the regulation of cell proliferation, differentiation, and survival. ZFHX3 has been shown to play a negative role in the development of cancer cells, and it has also been shown to be involved in the regulation of neurodegenerative diseases.

In addition to its role in cell signaling, ZFHX3 is also involved in the regulation of cellular processes that are important for tissue homeostasis. It is involved in the regulation of cell adhesion, migration, and the formation of tissues such as blood vessels.

As a potential drug target, ZFHX3 is an attractive target for researchers because of its involvement in several cellular processes that are important for normal tissue development and maintenance. It is also a good candidate for biomarker research, as its expression has been shown to be involved in several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

In conclusion, ZFHX3 is a protein that is involved in several critical cellular processes that are essential for normal tissue development and maintenance. Its involvement in cell signaling and its role in the regulation of cellular processes that are important for tissue homeostasis make it an attractive target for researchers. Furthermore, its potential as a drug target and biomarker make it an important molecule to study further.

Protein Name: Zinc Finger Homeobox 3

Functions: Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010)

More Common Targets

ZFHX4 | ZFHX4-AS1 | ZFP1 | ZFP14 | ZFP2 | ZFP28 | ZFP28-DT | ZFP3 | ZFP30 | ZFP36 | ZFP36L1 | ZFP36L2 | ZFP37 | ZFP41 | ZFP42 | ZFP57 | ZFP62 | ZFP64 | ZFP64P1 | ZFP69 | ZFP69B | ZFP82 | ZFP90 | ZFP91 | ZFP91-CNTF | ZFP92 | ZFPL1 | ZFPM1 | ZFPM2 | ZFPM2-AS1 | ZFR | ZFR2 | ZFTA | ZFTRAF1 | ZFX | ZFX-AS1 | ZFY | ZFYVE1 | ZFYVE16 | ZFYVE19 | ZFYVE21 | ZFYVE26 | ZFYVE27 | ZFYVE28 | ZFYVE9 | ZFYVE9P1 | ZG16 | ZG16B | ZGLP1 | ZGPAT | ZGRF1 | ZHX1 | ZHX1-C8orf76 | ZHX2 | ZHX3 | ZIC1 | ZIC2 | ZIC3 | ZIC4 | ZIC5 | ZIK1 | ZIM2 | ZIM3 | Zinc finger protein GLI | ZKSCAN1 | ZKSCAN2 | ZKSCAN3 | ZKSCAN4 | ZKSCAN5 | ZKSCAN7 | ZKSCAN8 | ZKSCAN8P1 | ZMAT1 | ZMAT2 | ZMAT3 | ZMAT4 | ZMAT5 | ZMIZ1 | ZMIZ1-AS1 | ZMIZ2 | ZMPSTE24 | ZMYM1 | ZMYM2 | ZMYM3 | ZMYM4 | ZMYM4-AS1 | ZMYM5 | ZMYM6 | ZMYND10 | ZMYND11 | ZMYND12 | ZMYND15 | ZMYND19 | ZMYND8 | ZNF10 | ZNF100 | ZNF101 | ZNF106 | ZNF107 | ZNF112