Target Name: ZFP42
NCBI ID: G132625
Other Name(s): ZNF754 | Zinc finger protein 42 homolog | Zinc finger protein 754 | Zfp-42 | OTTHUMP00000217834 | ZFP42 zinc finger protein | REX1 transcription factor | REX-1 | ZFP42 variant 1 | Reduced expression protein 1 | REX1 | ZFP42_HUMAN | zfp-42 | OTTHUMP00000217833 | hREX-1 | zinc finger protein 754 | ZFP42 zinc finger protein, transcript variant 1 | reduced expression protein 1

Stem Cell Regulator ZFP42: Potential Drug Target and Biomarker

ZFP42 (ZNF754) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a key regulator of stem cell proliferation and has been linked to a number of diseases, including neurodegenerative disorders, autoimmune diseases, and developmental disorders.

Recent studies have identified ZFP42 as a potential drug target for a number of diseases, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. ZFP42 has also been shown to be involved in a number of biological processes that are important for human health, including cell signaling, DNA replication, and cell division.

One of the key reasons for the potential clinical usefulness of ZFP42 is its ability to modulate the activity of other proteins. Studies have shown that when ZFP42 is overexpressed, it can cause a number of cellular changes, including increased cell proliferation and survival, and the formation of aggregates. These changes can lead to the development of a variety of diseases, including neurodegenerative disorders.

In addition to its potential as a drug target, ZFP42 has also been shown to be a valuable biomarker for a number of diseases. Studies have shown that ZFP42 levels can be affected by a variety of factors, including age, gender, and environmental conditions. By monitoring ZFP42 levels in disease tissues or fluids, researchers can gain important insights into the underlying biology of a variety of diseases.

Another promising aspect of ZFP42 is its ability to be targeted with small molecules. Studies have shown that a variety of small molecules have the potential to modulate ZFP42 activity and may be useful as drug candidates for the treatment of various diseases.

While the potential clinical usefulness of ZFP42 is still being explored, it is clear that it has the potential to be a valuable drug target and biomarker for a variety of diseases. Further research is needed to fully understand its biology and to develop safe and effective treatments for the various conditions that are associated with ZFP42 dysfunction.

Protein Name: ZFP42 Zinc Finger Protein

Functions: Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cell self-renewal (By similarity)

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