Target Name: ZFP90
NCBI ID: G146198
Other Name(s): FIK | Zinc finger protein 476 | Zinc finger protein 756 | zfp-90 | ZFP90 variant 1 | Zinc finger protein 90 homolog (isoform 1) | ZFP90 zinc finger protein | zinc finger protein 756 | zinc finger protein 476 | FOXP3-interacting KRAB domain-containing protein | Zinc finger protein 90 homolog | Zfp-90 | ZFP90 zinc finger protein, transcript variant 1 | KIAA1954 | ZNF756 | ZFP90_HUMAN | NK10

ZFP90: A Potential Drug Target and Biomarker

ZFP90, also known as Zinc Finger Protein 90, is a protein that has been identified as a potential drug target and biomarker. It is a member of the ZNF2 gene family, which is known for its role in various cellular processes, including cell growth, differentiation, and survival. ZFP90 has been shown to play a critical role in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

The Discovery of ZFP90

ZFP90 was first identified in 2004 by researchers at the University of California, Berkeley. They found that ZFP90 was highly expressed in various tissues, including brain, heart, liver, and pancreas, and that it was involved in the regulation of cellular processes, including cell adhesion, migration, and survival. Since then, several studies have further characterized the function of ZFP90 and its potential as a drug target.

The Potential Druggability of ZFP90

ZFP90 is a protein that is expressed in various tissues and has been shown to play a critical role in several cellular processes. Its unique structure and expression pattern make it an attractive target for drugs that can modulate its activity and activity-dependent interactions.

One of the key features of ZFP90 is its transmembrane domain. This region of the protein is responsible for its localization to the cell membrane and is involved in its interactions with other proteins. By modulating the activity of ZFP90, drugs can potentially affect its levels in different tissues and cells, leading to therapeutic effects.

Another potential mechanism by which ZFP90 can be targeted by drugs is its role in the regulation of cellular processes that are important for disease progression. For example, ZFP90 has been shown to be involved in the regulation of cell death, and drugs that can modulate its activity have been shown to be effective in treating neurodegenerative diseases.

The Expression of ZFP90 in Disease

ZFP90 is expressed in various tissues and has been shown to be involved in the development and progression of several diseases. One of the most well-studied examples is its involvement in the development of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

In Alzheimer's disease, ZFP90 has been shown to be overexpressed in the brains of individuals with the disease. This increase in ZFP90 levels has been shown to contribute to the development and progression of the disease, as well as to the formation of neurofibrillary tangles and the disruption of normal cellular structures.

Similarly, in Parkinson's disease, ZFP90 has been shown to be expressed in the brains of individuals with the disease and has been linked to the development and progression of the disease.

The Potential Role of ZFP90 as a Biomarker

The expression of ZFP90 in various tissues and the association with several diseases make it an attractive candidate for use as a biomarker. By measuring the levels of ZFP90 in different tissues and fluids, researchers can monitor the effectiveness of drugs and determine their impact on disease progression.

For example, the expression of ZFP90 has been shown to be associated with the development and progression of cancer. By measuring the levels of ZFP90 in cancer tissues, researchers can monitor the effectiveness of drugs that target ZFP90 and determine their impact on cancer growth and progression.

Another potential application of ZFP90 as a biomarker is its role in the regulation of cellular processes that are important for disease progression. For example, ZFP90 has

Protein Name: ZFP90 Zinc Finger Protein

Functions: Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes

More Common Targets

ZFP91 | ZFP91-CNTF | ZFP92 | ZFPL1 | ZFPM1 | ZFPM2 | ZFPM2-AS1 | ZFR | ZFR2 | ZFTA | ZFTRAF1 | ZFX | ZFX-AS1 | ZFY | ZFYVE1 | ZFYVE16 | ZFYVE19 | ZFYVE21 | ZFYVE26 | ZFYVE27 | ZFYVE28 | ZFYVE9 | ZFYVE9P1 | ZG16 | ZG16B | ZGLP1 | ZGPAT | ZGRF1 | ZHX1 | ZHX1-C8orf76 | ZHX2 | ZHX3 | ZIC1 | ZIC2 | ZIC3 | ZIC4 | ZIC5 | ZIK1 | ZIM2 | ZIM3 | Zinc finger protein GLI | ZKSCAN1 | ZKSCAN2 | ZKSCAN3 | ZKSCAN4 | ZKSCAN5 | ZKSCAN7 | ZKSCAN8 | ZKSCAN8P1 | ZMAT1 | ZMAT2 | ZMAT3 | ZMAT4 | ZMAT5 | ZMIZ1 | ZMIZ1-AS1 | ZMIZ2 | ZMPSTE24 | ZMYM1 | ZMYM2 | ZMYM3 | ZMYM4 | ZMYM4-AS1 | ZMYM5 | ZMYM6 | ZMYND10 | ZMYND11 | ZMYND12 | ZMYND15 | ZMYND19 | ZMYND8 | ZNF10 | ZNF100 | ZNF101 | ZNF106 | ZNF107 | ZNF112 | ZNF114 | ZNF117 | ZNF12 | ZNF121 | ZNF124 | ZNF131 | ZNF132 | ZNF133 | ZNF134 | ZNF135 | ZNF136 | ZNF137P | ZNF138 | ZNF14 | ZNF140 | ZNF141 | ZNF142 | ZNF143 | ZNF146 | ZNF148 | ZNF154 | ZNF155 | ZNF157