Study of Zinc Finger DHHC-Type Containing 18 (ZDHHC18) (G84243)

Target Name: ZDHHC18

NCBI ID: G84243

Study of Zinc Finger DHHC-Type Containing 18 (ZDHHC18)

Zinc Finger DHHC-Type Containing 18 (ZDHHC18) is a protein that is of interest as a potential drug target or biomarker. It is a zinc finger protein that is characterized by the presence of a zinc finger domain in its sequence. This domain is known for its ability to interact with various molecules, including small molecules, peptides, and proteins. ZDHHC18 has been shown to play a role in a variety of cellular processes, including cell signaling, DNA replication, and metabolism.

One of the key features of ZDHHC18 is its zinc finger domain. This domain is composed of four conserved amino acids that are known as zinc fingers. Zinc fingers are a class of short, highly variable conserved amino acid sequences, which usually consist of four Amino acid composition. Each residue in the zinc finger contains a zinc ion, which plays an important role in the function of the protein. For example, zinc fingers can bind to DNA and participate in DNA replication and transcription. It can also interact with many proteins and participate in signal transduction processes.

Another noteworthy feature is the conserved nature of ZDHHC18. It exists widely in a variety of organisms and can be expressed in a variety of tissues and organs. This indicates that ZDHHC18 has important biological functions in vivo. In addition, due to its conservation, ZDHHC18 is also considered as a potential drug target.

Recent studies have shown that ZDHHC18 plays an important role in a variety of diseases. For example, ZDHHC18 is upregulated in liver cancer, colon cancer, and breast cancer, and the expression level is positively correlated with disease progression and patient survival rate. These findings suggest that ZDHHC18 may be a potential drug target for the treatment of a variety of tumors.

In addition, ZDHHC18 is also closely related to a variety of metabolic processes. For example, it plays a role in glucose and fatty acid metabolism and is involved in intracellular fat synthesis. These findings provide important clues for studying the role of ZDHHC18 in metabolic diseases.

In summary, Zinc Finger DHHC-Type Containing 18 (ZDHHC18) is a protein worth studying. Its zinc finger domain and conservation suggest that it may be a potential drug target or biomarker. In the future, researchers can further study the role of ZDHHC18 in cell signaling, DNA replication, metabolism, and tumorigenesis to better understand its biological functions.

Protein Name: Zinc Finger DHHC-type Palmitoyltransferase 18

Functions: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK (PubMed:23034182, PubMed:27481942, PubMed:35438208). Acts as a negative regulator of the cGAS-STING pathway be mediating palmitoylation and inactivation of CGAS (PubMed:35438208). May also have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling (PubMed:27481942)

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